ArticleJournal of experimental pharmacology2026
Hesperidin Mitigates Bisphenol-A Induced Oxidative Stress, Endocrine Disruption and Testicular Damage in Adult Male Wistar Rats.
Article in Journal of experimental pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Bisphenol A (BPA), a well-known endocrine disruptor, is newly emerging as causing male infertility by endocrine disturbances, induction of oxidative stress and testicular toxicity. This study investigates the protective role of hesperidin against BPA-induced testicular toxicity in male Wistar rats. Methodology: The rats were divided into six groups (n=7): control (normal saline); BPA-only (50 mg/kg); hesperidin-only at 50 mg/kg and 100 mg/kg; and two pre-treated groups receiving hesperidin (50 and 100 mg/kg) followed by BPA (50 mg/kg). All treatments were administered orally for 8 weeks. Post-treatment analyses included testicular weight, volume, and diameter measurements; serum testosterone, FSH, and LH levels; oxidative stress markers (MDA, SOD, CAT, GPx, and GSH); and histological and morphometric evaluation of the testis. Result and Discussion: BPA exposure significantly reduced testicular dimensions, decreased serum testosterone, FSH, and LH. Histopathological examination revealed degeneration of seminiferous tubules, germ-cell depletion, reduced counts of spermatogonia, spermatocytes, spermatids, Sertoli and Leydig cells. BPA significantly induced oxidative stress, evidenced by increased MDA and decreased SOD, CAT, GPx, and GSH. Hesperidin significantly mitigated these effects by restoring testicular morphology, hormonal profiles, enhancing oxidative stress markers, improving histology and cell populations. Conclusion: Hesperidin demonstrates protective properties against BPA-induced testicular and endocrine toxicity in rats, likely as a result of its antioxidant properties.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.