ArticleRegenerative biomaterials2026
A 'frost formation'-inspired near-infrared-responsive nitric oxide-releasing hydrogel for enhancing fat graft survival.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Soft tissue defects represent a major challenge in plastic surgery, for which autologous fat grafting remains the standard treatment. However, in the early post-transplant period, the grafted fat tissue undergoes ischemia and hypoxia, leading to low and markedly unpredictable survival rates that consequently compromise the aesthetic outcomes. Nitric oxide (NO), an endogenous gasotransmitter, plays a vital role in mediating angiogenesis and vascular remodeling. Therefore, we developed a near-infrared-responsive hydrogel that releases NO on demand to promote adipocyte vascularization and thereby improve graft retention and enable precise volumetric filling. To ensure high filling, the platform incorporates a photosensitive gelatin methacryloyl (GelMA) hydrogel inspired by the rapid solidification of 'frost formation'. The hydrogel can be precisely delivered to the target area and photocrosslinked
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