Evidence map›Paper›PMID 42207225›Full record

ArticleMolecular biology reports2026

Erythrina caffra extract restores memory, modulates cholinergic dysfunction, neuroinflammation, and attenuates oxidative stress in cadmium-induced alzheimer's disease-like pathology in rats.

Soumia Ed-Day, Fatima Ezzahra Kacimi, Radia El Gui, Latifa Didou, Laila Ibouzine-Dine, Chaimae El Kourchi, Samira Boulbaroud, Azzouz Haddan, Hicham Harhar, Fatima-Zahra Azzaoui

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Soumia Ed-DayDepartment of Biology, Biology & Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco. soumia.edday@uit.ac.ma.
Fatima Ezzahra KacimiDepartment of Biology, Polydisciplinary Faculty, Sultan Moulay Slimane University, Béni Mellal, Morocco.
Radia El GuiDepartment of Biology, Biology & Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Latifa DidouDepartment of Biology, Biology & Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Laila Ibouzine-DineDepartment of Biology, Biology & Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Chaimae El KourchiDepartment of Chemistry, Faculty of Sciences, Mohamed V University, Rabat, Morocco.
Samira BoulbaroudDepartment of Biology, Polydisciplinary Faculty, Sultan Moulay Slimane University, Béni Mellal, Morocco.
Azzouz HaddanAnatomo-Cytopathology Department, Azzamouri Hospital Center, Kenitra, Morocco.
Hicham HarharDepartment of Chemistry, Faculty of Sciences, Mohamed V University, Rabat, Morocco.
Fatima-Zahra AzzaouiDepartment of Biology, Biology & Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCadmium (Cd) is a well-established neurotoxic heavy metal. Several epidemiological studies have highlighted its involvement in the pathogenesis of Alzheimer's disease (AD). AD is a multifactorial disorder influenced by environmental factors such as heavy metals. Erythrina caffra (E. caffra) is a medicinal plant rich in bioactive compounds with anti-inflammatory, antioxidant, and anticholinesterase properties. However, its protective potential against Cd-induced neurodegeneration remains insufficiently explored. This study investigated the effects of Cd on memory, cholinergic function, oxidative stress, and neuroinflammation, as key AD-related pathophysiological features, and evaluated the therapeutic potential of E. caffra seeds ethanolic extract. METHODS AND

resultsAD-like alterations were induced in Wistar rats by intracerebroventricular (ICV) administration of cadmium chloride (CdCl

conclusionsE. caffra extract demonstrates neuroprotective effects against Cd-induced AD-like pathology by modulating oxidative stress, neuroinflammation, and cholinergic dysfunction. These findings suggest its potential as a promising therapeutic candidate for mitigating neurodegenerative processes associated with AD.

Indexed as

Alzheimer DiseaseErythrinaMemoryPlant ExtractsAcetylcholineAnimalsAntioxidantsCadmiumDisease Models, AnimalHippocampusMaleNeuroinflammatory DiseasesNeuroprotective AgentsOxidative StressRatsRats, WistarAcetylcholineAntioxidantsCadmiumNeuroprotective AgentsPlant ExtractsAlzheimer’s diseaseCadmiumErythrina caffraMemoryNeuroinflammationOxidative stress

Identifiers

PMID42207225

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.