Evidence map›Paper›PMID 42208263›Full record

ArticleRedox biology2026

Fenofibrate alleviates the brain edema after traumatic brain injury by enhancing endothelial OXPHOS.

Qiyuan Feng, Yingwei Gao, Xiaokun Gu, Xinxin Zhao, Xinwen Liu, Zixuan Ma, Wenlan Qi, Zhenghui He, Yuhan Han, Jian Zhang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Qiyuan FengBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Yingwei GaoBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Xiaokun GuBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Xinxin ZhaoDepartment of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Xinwen LiuShanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zixuan MaBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Wenlan QiBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Zhenghui HeBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Yuhan HanBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Jian ZhangBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Wenye WangBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Zhifan LiBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Daiwen ZhangBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Jialin HuangShanghai Institute of Head Trauma, Shanghai, 200127, China.
Yong LinShanghai Institute of Head Trauma, Shanghai, 200127, China.
Jiyuan HuiBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Bayasgalan OnondariDepartment of Brain and Craniofacial Surgery, National Trauma and Orthopaedic Research Center of Mongolia, Ulaanbaatar, 16092, Mongolia.
Galbadrakh ErdenetsetsegAdministrative Office, National Trauma and Orthopaedic Research Center of Mongolia, Ulaanbaatar, 16092, Mongolia.
Qing MaoBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Jiyao JiangBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China.
Yan ZhouDepartment of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Electronic address: clare1475@hotmail.com.
Weiji WengBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China. Electronic address: zigzagweng@163.com.
Yan ZhangThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China; Jiangxi Academy of Medical Sciences, Nanchang, Jiangxi, 330006, China; Nanchang Cranio-Cerebral Trauma Laboratory, Nanchang, Jiangxi, 330006, China. Electronic address: ndefy12388@ncu.edu.cn.
Junfeng FengBrain Injury Centre, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China; Shanghai Institute of Head Trauma, Shanghai, 200127, China. Electronic address: fengjfmail@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) frequently leads to brain edema, a life-threatening complication and a major cause of mortality and disability. Here, we report that fenofibrate (FFB), an agonist of the nuclear receptor peroxisome proliferator-activated receptor-α (PPARα), alleviates post-traumatic brain edema by enhancing blood-brain barrier (BBB) integrity in a mouse model of severe TBI. Mechanistic studies in cultured endothelial cells and endothelial-specific PPARα conditional knockout mice revealed that FFB activates PPARα, enhances mitochondrial oxidative phosphorylation (OXPHOS), and thereby reduces oxidative stress and endothelial cell apoptosis. These findings identify PPARα-dependent enhancement of energy metabolism in the brain endothelium as a promising therapeutic strategy for TBI-induced edema.

Indexed as

Brain EdemaBrain Injuries, TraumaticFenofibrateOxidative PhosphorylationAnimalsApoptosisBlood-Brain BarrierDisease Models, AnimalEndothelial CellsHumansMaleMiceMice, KnockoutMitochondriaOxidative StressPPAR alphaFenofibratePPAR alphaBrain edemaFenofibrate (FFB)Oxidative phosphorylation (OXPHOS)Traumatic brain injury (TBI)

Identifiers

PMID42208263
PMCPMC13241661

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.