Observational studyBMJ paediatrics open2026
Comparing extracellular vesicle enriched plasma proteomes between term and preterm neonates over the first days of life: post hoc analysis of a prospective observational study.
Observational study in BMJ paediatrics open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundWhile cardiopulmonary transition in neonates is well described, molecular changes which accompany it are not. The Extracellular Vesicles in Early preterm neonates and Thrombin generation (EVENT) study sought to explore molecular transition in preterm birth. How this differs from term-born neonates is not well described.
methodsA post hoc evaluation of proteomic data generated from a subset of the prospective, single site observational EVENT study was performed comparing extracellular vesicle enriched plasma from term neonates (n=10) with preterm neonates (n=20) using a mass spectrometry, data dependent acquisition-based proteomic approach. Bioinformatics was performed using MaxQuant proteomics software and R statistical software.
resultsSubstantial differences were found between the preterm and term extracellular vesicle proteome, with proteins involved in extracellular matrix biology, immune function and embryogenesis all differentially expressed. Preterm neonates could be identified by their proteomic profile alone, reflecting their distinct physiology.
conclusionsThese protein expression differences may underlie the pathogenesis of complications of prematurity, such as bronchopulmonary dysplasia, retinopathy of prematurity and intraventricular haemorrhage.
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