Altered Properties of Bone Marrow-Derived Mesenchymal Stem Cells Exposed to Serum from Patients with Acute-On-Chronic Liver Failure.

Wenxin Zhang, Shurong Liu, Zhiru Wang, Chang Sun, Baikun Liu, Lei Zhang

Abstract read

In one paragraph

Article in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenxin ZhangDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, China.ORCID https://orcid.org/0009-0003-5113-6151

Shurong LiuCentral Laboratory, Hepatobiliary Disease Hospital of Jilin Province, Changchun, China.ORCID https://orcid.org/0009-0008-5619-2407

Zhiru WangCentral Laboratory, Hepatobiliary Disease Hospital of Jilin Province, Changchun, China.ORCID https://orcid.org/0009-0002-7041-3903

Chang SunCentral Laboratory, Hepatobiliary Disease Hospital of Jilin Province, Changchun, China.ORCID https://orcid.org/0009-0007-0042-4021

Baikun LiuCentral Laboratory, Hepatobiliary Disease Hospital of Jilin Province, Changchun, China.ORCID https://orcid.org/0009-0003-5298-1357

Lei ZhangDepartment of Cardiology, China-Japan Union Hospital of Jilin University (Xinmin Campus), Changchun, China.ORCID https://orcid.org/0009-0008-7279-8329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute-on-chronic liver failure (ACLF) is a high-mortality syndrome characterized by acute decompensation of liver function. Oxidative stress exerts a pivotal regulatory role in ACLF. Mesenchymal stem cell (MSC)-based therapy is a promising strategy for ACLF, with well-documented safety and efficacy profiles. However, long-term exposure to an oxidative microenvironment can impair MSC regenerative capacity and trigger senescence. Thus, elucidating how the pathological ACLF serum microenvironment affects the biological characteristics of MSCs is important for advancing MSC-based therapeutic strategies. This study investigated the biological alterations of MSCs exposed to ACLF patient serum. We demonstrated that ACLF serum markedly impaired MSC morphology, proliferation, and migration, induced energy metabolism dysfunction, and promoted senescence

Indexed as

Acute-on-chronic liver failureAdvanced oxidation protein productsAgingCell proliferationEnergy metabolismReactive oxygen species

Identifiers

PMID42209407

DOI10.15283/ijsc25085

PMCPMC13218836

What Socratic holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.