ArticleScientific reports2026
Accelerometer-derived physical activity, sarcopenia, and grip strength as modifiers of type 2 diabetes risk.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Physical activity (PA) represents a modifiable protective factor against type 2 diabetes mellitus (T2DM), whereas sedentary behavior is recognized as a significant risk factor. However, uncertainties remain regarding the dose-response relationships across different PA intensities, the impact of sarcopenia status, and potential interactions between muscle function and PA. This prospective cohort study included 89,532 UK Biobank participants. PA and sedentary behavior were measured by wrist accelerometers. PA included total volume of PA, moderate-to-vigorous PA (MVPA), and light-intensity PA (LPA). Sarcopenia status was defined using EWGSOP2 criteria including grip strength, muscle mass, and walk pace. Cox proportional hazards models estimated associations with incident T2DM over median seven years of follow-up, adjusting for sociodemographic, lifestyle, and clinical factors. Higher levels of total PA and guideline-recommended MVPA were associated with reduced T2DM risk. Sedentary time showed a positive linear association (P for linearity < 0.001, P for nonlinearity = 0.969). A slow walking pace (HR = 1.82, 95% CI: 1.57-2.10) and severe muscle mass deficit (HR = 1.15, 95% CI: 1.00-1.32) were independent risk factors. Crucially, grip strength modified PA-T2DM associations: higher PA reduced risk significantly only in participants with normal grip strength (HR = 0.60, 95% CI: 0.53-0.69) but not in those with low grip strength (HR = 1.06, 95% CI: 0.74-1.51; P for interaction < 0.05). Accelerometer-measured PA demonstrated dose-dependent protective effects against T2DM, whereas components of sarcopenia were independently associated with an increased risk. Notably, preserved grip strength enhances these benefits, suggesting that muscle function assessment can optimize personalized prevention strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.