Evidence map›Paper›PMID 42209655›Full record

ArticleCommunications biology2026

Quantitative LC-MS/MS profiling reveals aberrant chondroitin sulfate in Alzheimer's disease.

Yongmei Xu, Haoran Wang, Zhangjie Wang, Jianxiang Zhang, Eduardo Stancanelli, Qin Xu, Yiru Hou, Chunyu Wang, Peng Zhang, Marla Gearing and 1 more

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongmei Xu *Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Haoran Wang *Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-2781-6264
Zhangjie WangGlycan Therapeutics Corp, Raleigh, NC, USA.
Jianxiang ZhangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Eduardo StancanelliGlycan Therapeutics Corp, Raleigh, NC, USA.
Qin XuDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Yiru HouGlycan Therapeutics Corp, Raleigh, NC, USA.
Chunyu WangDepartment of Biological Sciences, Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Peng ZhangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Marla GearingDepartment of Pathology and Laboratory Medicine and Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Jian LiuDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. jian_liu@unc.edu.ORCID 0000-0001-8552-1400

Funding

The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's DiseaseRF1AG069039 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J, LIU, JIAN · 2020 to 2020
$2.6M
Development of anticoagulant sulfated glycansR44GM148100 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI PAGADALA, VIJAYAKANTH · 2023 to 2025
$2.5M
Development of heparan sulfate-based therapeutics to treat inflammatory diseasesR44GM144019 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI WANG, ZHANGJIE · 2023 to 2025
$2.4M
ApoE and Heparan Sulfate Interaction in Alzheimer’s DiseaseR01AG087305 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI JIAN LIU, Chunyu Wang · 2024 to 2026
$2.3M
Development of analytical methods for glycosaminoglycans from biological sourcesR44GM142304 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI WANG, ZHANGJIE · 2022 to 2023
$2.0M
The role of heparan sulfate modification on neurexin1 in synapse developmentR01MH130476 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI peng zhang · 2024 to 2026
$1.3M
Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and BiologyT32AG078123 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI Chunyu Wang · 2023 to 2026
$974k
Rensselaer Alzheimer’s Fellows to Accelerate Entrepreneurship in Life Sciences (RAFAELs)R25AG088409 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI Jonathan S. Dordick, ERIC H LEDET · 2024 to 2026
$773k
Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's DiseaseR01AG069039 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J, LIU, JIAN · 2024 to 2024
$555k
Quantitative analysis of heparan sulfate using 13C-labeled standardsR43GM142304 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI PAGADALA, VIJAYAKANTH · 2021 to 2021
$300k
Development of heparan sulfate-based therapeutics to treat inflammatory diseasesR43GM144019 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI ARNOLD, KATELYN · 2021 to 2021
$231k
NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG069039NIA NIH HHS R01 AG087305NIA NIH HHS R25 AG088409NIA NIH HHS RF1 AG069039NIA NIH HHS T32 AG078123NIGMS NIH HHS R43 GM142304NIGMS NIH HHS R43 GM144019NIGMS NIH HHS R44 GM142304NIGMS NIH HHS R44 GM144019NIGMS NIH HHS R44 GM148100NIMH NIH HHS R01 MH130476U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) AG069039, GM144019, GM148100, MH130476, AG078123, AG088409, and AG066511U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) AG087305U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) GM142304
6 · The paper itself

Abstract

Chondroitin sulfate (CS) is an essential sulfated glycan in the brain, but standard LC-MS/MS disaccharide analysis provides only limited quantitative accuracy for detecting CS structural changes under physiological and pathophysiological conditions. Here, we incorporated eight distinct

Indexed as

Alzheimer DiseaseChondroitin SulfatesTandem Mass SpectrometryAnimalsBiomarkersBrainChromatography, LiquidHumansLiquid Chromatography-Mass SpectrometryBiomarkersChondroitin Sulfates

Identifiers

PMID42209655
PMCPMC13500702

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.