Evidence map›Paper›PMID 42210121›Full record

ArticleBMC nephrology2026

Urinary Vanin-1 in the detection of acute kidney injury in humans.

Konstantinos Markakis, Panagiota Zgoura, Maximilian Seidel, Jonas Franz Kolodziej, Sonja Rieckmann, Sebastian Bertram, Adrian Doevelaar, Benjamin Rohn, Nina Babel, Timm Westhoff and 1 more

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Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Konstantinos Markakis *Medical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.ORCID 0000-0001-7784-2490
Panagiota Zgoura *Medical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Maximilian SeidelMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Jonas Franz KolodziejMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Sonja RieckmannMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Sebastian BertramMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Adrian DoevelaarMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Benjamin RohnMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Nina BabelMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Timm WesthoffMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.
Felix SeibertMedical Department I, University Hospital Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany. felix.seibert@elisabethgruppe.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFormer studies indicate, that urinary Vascular Non-Inflammatory Molecule 1 (Vanin-1) may be an early biomarker of acute tubular necrosis. We evaluated the diagnostic performance of Vanin-1 regarding the detection of acute kidney injury (AKI) and the differentiation of prerenal from intrinsic AKI compared to other known biomarkers. MATERIALS AND

methodsUrinary Vanin-1, Neutrophil gelatinase-associated Lipocalin (NGAL), Kidney injury molecule 1 (KIM-1) and calprotectin concentrations were assessed in 112 hospitalized subjects, 51 with intrinsic and 61 with prerenal AKI. 27 healthy subjects served as controls. Exclusion criteria were postrenal AKI or renal transplantation. Only patients with severe AKI were eligible. Results were expressed as urinary creatinine ratios.

resultsMedian urinary Vanin-1/creatinine was significantly higher in patients with AKI (1912 [812.1-4808] vs. 344.2 [165.2-553.4] pg/mg, p = 0.001; AUROC 0.86 [95% CI 0.80-0.93], p = 0.001). The AUROC for NGAL-, KIM-1- and calprotectin/creatinine were 0.92 (95% CI 0.87-0.97; p = 0.001), 0.96 (95% CI 0.92-0.99; p = 0.001), 0.82 (95% CI 0.74-0.90; p = 0.001), respectively. The diagnostic accuracy of urinary Vanin-1/creatinine in the differentiation of prerenal from intrinsic AKI was low (AUROC 0.64 [95% CI 0.54-0.75, p = 0.01]). The respective AUROCs for NGAL/creatinine, calprotectin/creatinine and KIM-1/creatinine were 0.71 ([95% CI 0.61-0.80], p = 0.001), 0.77 ([95% CI 0.68-0.86], p = 0.001) and 0.54 ([95% CI 0.44-0.65], p = 0.001).

conclusionTo our knowledge, this is one of the largest human studies evaluating urinary Vanin-1 in AKI. Urinary Vanin-1/creatinine ratio was higher in patients with AKI compared to controls. However, its diagnostic accuracy in the differentiation of intrinsic from prerenal AKI was lower than of other biomarkers.

Indexed as

Acute Kidney InjuryAmidohydrolasesAdultAgedBiomarkersCreatinineFemaleGPI-Linked ProteinsHepatitis A Virus Cellular Receptor 1HumansLeukocyte L1 Antigen ComplexLipocalin-2MaleMiddle AgedAmidohydrolasesBiomarkersCreatinineGPI-Linked ProteinsHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1LCN2 protein, humanLeukocyte L1 Antigen ComplexLipocalin-2pantetheinaseAcute kidney injuryBiomarkerIntrinsicPrerenalVanin-1

Identifiers

PMID42210121
PMCPMC13227639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.