ArticleJournal of translational medicine2026
Associations of long-term average and variability of estimated glucose disposal rate with frailty progression: evidence from two prospective cohorts.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe estimated glucose disposal rate (eGDR), when measured at a single time point, has been linked to frailty. This study aimed to investigate the associations between long-term eGDR patterns and frailty progression.
methodsWe conducted prospective analyses among participants aged ≥ 45 years from two cohorts: the Health and Retirement Study (HRS) and the English Longitudinal Study of Ageing (ELSA). Two metrics were derived to characterize long-term eGDR patterns over an 8-year exposure period: average eGDR and eGDR variability (assessed by variation independent of the mean [VIM]). The frailty index (FI, 0-100 points) was calculated every two years during the follow-up period, with higher scores indicating more severe frailty. Linear mixed-effects models were used to analyze the associations of long-term eGDR patterns with frailty progression.
resultsThis study included 6,829 participants from HRS (mean age: 67.7 years, 60.0% females) and 2,152 participants from ELSA (mean age: 69.7 years, 56.5% females). Compared with individuals in the lowest tertile (T1) of average eGDR, those in the highest tertile (T3) showed a significantly slower increase in FI over time (pooled β: -0.347, 95% CI: -0.536 to -0.157; I
conclusionsBoth long-term average and variability of eGDR were associated with frailty progression, highlighting the importance of monitoring eGDR dynamics and implementing interventions to stabilize eGDR in aging populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.