Evidence map›Paper›PMID 42210713›Full record

ArticlePhysiological reports2026

Novel interactions between the C5-C5aR1 Axis and IF1: Implications for kidney mitochondrial physiology and ischemia-reperfusion injury.

Madison McGraw, Amod Sharma, Dinesh Bhattarai, Neriman Gokden, LeeAnn Macmillan-Crow, Nirmala Parajuli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madison McGrawDepartment of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID https://orcid.org/0009-0008-5602-1982
Amod SharmaDepartment of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Dinesh BhattaraiDepartment of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Neriman GokdenDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
LeeAnn Macmillan-CrowDepartment of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Nirmala ParajuliDepartment of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0003-3994-5338

Funding

Targeting heat shock protein 72 to improve renal function after transplantationR01DK123264 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI PARAJULI, NIRMALA · 2021 to 2025
$2.4M
American Heart Association (AHA) 19TPA34850057NIDDK NIH HHS R01 DK123264
6 · The paper itself

Abstract

Ischemia-reperfusion injury (IRI) is a prevalent condition that predominantly afflicts hospitalized patients, inducing acute kidney injury (AKI). In recent years, complement 5 (C5) and its anaphylatoxin receptor C5aR1 have been implicated in driving kidney IRI and loss of function. Beyond this, prior studies suggest C5-C5aR1 mediates mitochondrial ROS production, although its role in the mitochondria has never been fully characterized. Here, we leverage a previously generated model of C5 gene deletion (male C5

Indexed as

Acute Kidney InjuryComplement C5KidneyMitochondriaReceptor, Anaphylatoxin C5aReperfusion InjuryAnimalsATPase Inhibitory ProteinMaleRatsSignal TransductionATPase Inhibitory ProteinComplement C5Receptor, Anaphylatoxin C5aATPase inhibitory factor 1Avacopancomplement 5kidney injurymitochondria

Identifiers

PMID42210713
PMCPMC13239135

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.