A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery.

Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi-Tao Yang, Yong Fan, Xiaodong Zhu

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiahao GuoDepartment of Nanomedicine, Naval Medical University, Shanghai, P. R. China.

Yuanyuan MengDepartment of Nanomedicine, Naval Medical University, Shanghai, P. R. China.

Qixiang GuiSchool of Medicine, Department of Plastic and Reconstructive Surgery of Shanghai East Hospital, Tongji University, Shanghai, P. R. China.ORCID https://orcid.org/0009-0005-8590-1258

Xi-Tao YangDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China.

Yong FanDepartment of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Ichem, Fudan University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-5220-9445

Xiaodong ZhuDepartment of Nanomedicine, Naval Medical University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-4759-7364

Funding

National Natural Science Foundation of China 22222403National Natural Science Foundation of China 22574030National Natural Science Foundation of China 82503551

6 · The paper itself

Abstract

Diabetic wound healing is still a challenge, because the pathological microenvironment is characterized by a vicious cycle of oxidative stress, hypoxia, infection and chronic inflammation. Herein, we report a near-infrared (NIR) light-activated cascade nanodressing incorporated into a sprayable hyaluronic acid hydrogel. Under NIR irradiation, MXene serves not only as a photothermal substrate but also generates an interfacial electronic effect that drastically enhances the multienzyme-mimicking activities of zinc hexacyanoferrate (ZnHCF), enabling efficient ROS clearance and alleviation of hypoxia. The mild photothermal effect further triggers-controlled release of deferoxamine (DFO), which cooperates with ZnHCF to chelate free iron ions, thereby suppressing ROS generation at the source. The system also exhibits synergistic photothermal-nanoknife-Zn

Indexed as

cascade reactiondiabetic wound healingMXenenanozymessynergistic therapy

Identifiers

PMID42210786

DOI10.1002/advs.75886

PMCPMC13335989

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.