ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity.
Yi Chen, Zhao-Yu Liu, Gao-Wen Qu, Run-Hao Zeng, Wen-Xia Yao, Yong-Bing Zhou, Xue Liang, Yu-Xiong Lai
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Yi ChenKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0006-0625-2200 Zhao-Yu LiuKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Gao-Wen QuKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Run-Hao ZengKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wen-Xia YaoKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yong-Bing ZhouKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xue LiangKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3591-0947 Yu-Xiong LaiKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-9022-4520 Funding
Guangzhou Major Medical Disciplines ProjectNational Natural Science Foundation of China 82202985University-City Joint General Project of Guangzhou Science and Technology Bureau 2024A03J0066
6 · The paper itselfAbstract
Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD. Clinically, PANX2 expression is downregulated during tumor progression, and low PANX2 levels correlate with poor prognosis. Functionally, PANX2 overexpression induces disulfidptosis in LUAD cells through two convergent axes: (i) activating NRF2 via Ca
Indexed as
Adenocarcinoma of LungConnexinsDisulfidptosisLung NeoplasmsAnimalsCell Line, TumorDisease ProgressionHumansMiceConnexinsATP signalingcancer immunitydisulfidptosisG6PDlung adenocarcinomaNRF2PANX2
Identifiers
PMID42210821
PMCPMC13335910
What Socratic holds
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