ArticlePain research & management2026
Paraspinal Muscle Fatty Infiltration as a Predictor of Intervertebral Disc Degeneration and Pain Severity in Chronic Low Back Pain.
Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Paraspinal Muscle Fatty Infiltration as a Predictor of Intervertebral Disc Degeneration and Pain Severity in Chronic Low Back Pain.Pain research & management · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundChronic low back pain (CLBP) is commonly associated with paraspinal muscle fatty infiltration and intervertebral disc degeneration (IDD); however, their independent contributions to pain and disability, as well as the influence of Body Mass Index (BMI) on these associations, remain unclear.
objectiveThis study aimed to investigate the associations of paraspinal muscle fatty infiltration rate (FIR) and cross-sectional area (CSA)-specifically of the multifidus (MF), erector spinae (ES), and psoas major (PM)-with IDD severity, clinical metrics (pain (Visual Analog Scale [VAS]) and disability (Oswestry Disability Index [ODI])), and demographic factors (age, sex, and BMI) in patients with CLBP.
methodsA cross-sectional study included 118 CLBP patients. FIR and CSA of paraspinal muscles at L2-S1 were quantitatively measured on MRI using ImageJ. IDD was graded using the Pfirrmann system. Correlations and group comparisons were statistically analyzed.
resultsFIR showed significant sex-based differences but no left-right asymmetry and was not associated with BMI. MF FIR was strongly positively correlated with Pfirrmann grade (r > 0.7, p < 0.05). FIR of MF and ES was positively correlated with age and disease duration, as well as VAS and ODI scores (r > 0.6, p < 0.05), whereas CSA showed only weak correlations. The PM exhibited minimal associations with clinical or degenerative parameters.
conclusionParaspinal muscle fatty infiltration, especially in the MF and ES, is strongly associated with IDD severity, pain, and disability independently of BMI. FIR could serve as a potential imaging biomarker for assessing CLBP severity and progression.
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