ArticleMaterials today. Bio2026
Self-assembled nanoparticles from natural herbs alleviate osteoarthritis by targeting retinol metabolism and inhibiting chondrocyte ferroptosis.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteoarthritis (OA), a prevalent degenerative joint disease, currently lacks effective therapies. Self-assembled nanomedicines derived from herbs create innovative pharmaceutical formulations, and offer promising therapeutic strategies for OA treatment. Considering the treatment of Shen-Sui-An-Kang (SSAK) decoction in clinical OA symptoms, here we isolated the nanoparticles from SSAK decoction, and then investigated their effects on OA treatment. By using gradient centrifugation and dialysis, self-assembled nanoparticles of SSAK (N-SSAK) were isolated based on the hydrophobic interactions, hydrogen bonding, and π-π stacking. After determining the physical characteristics of N-SSAK, we investigated the therapeutic effect of N-SSAK
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