SynthesisFrontiers in psychiatry2026
Homocysteine and cognitive function in depression: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to assess the association between homocysteine (Hcy) levels and cognitive function in individuals with depression using a systematic review and meta-analysis. Methods: We searched PubMed, Web of Science, EMBASE, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and the Chinese Science and Technology Journal Database (VIP) for studies reporting Hcy levels and cognitive outcomes in patients with depression from inception to December 2025. Methodological quality was assessed using the Agency for Healthcare Research and Quality (AHRQ) checklist, evidence certainty was evaluated using the GRADE approach, and meta-analyzes were performed using random-effects models in Stata 17.0. Results: A total of 13 studies involving 1,269 patients with depression were included. The meta-analysis showed a significant inverse association between Hcy levels and cognitive scores ( Conclusions: Hcy levels are associated with CogI in patients with depression, and subgroup analyzes and leave-one-out sensitivity analyzes indicate that the direction of the association is generally consistent. Further prospective studies are needed to clarify the clinical relevance of Hcy and whether it may contribute to the assessment of cognitive impairment in depression. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251206956.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.