ReviewJournal of inflammation research2026
Mental Health Disorders in Pediatric Inflammatory Bowel Disease: Epidemiology, Mechanisms, and Interventions.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to synthesize current evidence on the association between pediatric inflammatory bowel disease (IBD) and mental health disorders, with a focus on epidemiology, underlying pathophysiological mechanisms, and advances in screening and intervention strategies. Pediatric IBD is increasingly recognized as a condition with substantial psychological as well as gastrointestinal burden. Children and adolescents with IBD have a markedly higher prevalence of mental health disorders than the general population, most commonly depression, anxiety, and sleep disorders, with risk appearing particularly higher in adolescents and in those with Crohn's disease. Based on psychiatric evaluations, the prevalence of mental disorders in this population ranges from 42% to 73%. Accumulating evidence suggests a complex, bidirectional relationship between intestinal inflammation and mental health, mediated through interacting mechanisms that include gene-environment interactions, dysregulation of the gut-brain axis, immune imbalance, and medication-related effects. Although several validated screening tools for anxiety and depression have been introduced into clinical practice, mental health disorders in pediatric IBD remain frequently underrecognized and undertreated. Psychological interventions, family-centered care models, and pharmacologic treatments show potential benefit, but evidence in pediatric populations is limited and largely extrapolated from adult studies. Greater clinical awareness, routine mental health screening, and integrated multidisciplinary care interventions are essential to improve outcomes. Future large-scale, multi-center, and longitudinal studies are needed to clarify underlying mechanisms and optimize prevention and treatment strategies. Unlike previous reviews that often combine adult and pediatric populations, this review specifically focuses on pediatric-onset IBD and provides a dedicated synthesis of mental health comorbidities in children and adolescents.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.