Evidence mapPaperPMID 42211235Full record

ReviewJournal of inflammation research2026

Regulatory T Cells in Diabetic Wound Healing: A Comprehensive Review.

Jiezhi Lin, Yingying Liu, Peiyao Min, Hui Zhao, Zhaofan Xia, Yongjun Zheng

Abstract readReview
In one paragraph

Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiezhi Lin *Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.ORCID 0009-0006-3592-6059
Yingying Liu *Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
Peiyao Min *Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
Hui ZhaoDepartment of Burn Surgery, The 963rd Hospital of Joint Logistics Support Force of PLA, Jiamusi, Heilongjiang, 154007, People's Republic of China.
Zhaofan XiaDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
Yongjun ZhengDepartment of Burn Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with diabetes frequently face challenges associated with impaired wound healing, which is a serious clinical concern. Regulatory T cells (Tregs) are essential immune modulators that are integral to wound healing. While research is increasingly examining alterations in Tregs and their potential impacts on diabetic wound healing, a comprehensive review is lacking. This review employs a narrative approach to summarize the current knowledge regarding the mechanisms by which Tregs influence wound healing in diabetes, focusing on their impact on inflammatory responses, cellular regeneration, and angiogenesis. Furthermore, we investigated the potential therapeutic applications of Tregs in diabetic wound healing, highlighting recent advances in biomaterials, molecular pathways, and regulatory strategies targeting Tregs. Despite challenges such as cell acquisition and quality control, as well as risks like immunosuppression and infection, advancements in clinical studies indicate that Tregs could be a promising new treatment for diabetes. This review aims to provide novel insights and directions by analyzing the most recent literature on future therapeutic strategies for managing diabetic wounds.

Indexed as

diabetesimmune modulationtregswound healing

Identifiers

PMID42211235
PMCPMC13212173

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.