SynthesisFrontiers in neurology
Efficacy of non-pharmacological treatments for prolonged disorders of consciousness: a network meta-analysis of randomized controlled trials.
Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the efficacy of non-pharmacological treatments such as repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), median nerve stimulation (MNS), hyperbaric oxygen (HBO), and acupuncture in improving the level of consciousness in patients with prolonged disorders of consciousness (pDOC). Methods: PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, China Biology Medicine (CBM), and VIP Database were systematically searched from inception to December 2024. Data synthesis and visualization were conducted using the "coda" and "gemtc" packages in R software and STATA 17.0. The Jadad scale was used for initial screening to exclude low-quality studies, and the Cochrane Risk of Bias 2.0 tool was applied to assess the methodological quality of included randomized controlled trials (RCTs). Results: A total of 32 randomized controlled trials (RCTs) enrolling 1,770 participants were included in this network meta-analysis. The pooled results demonstrated that rTMS, tDCS, MNS, HBO, and acupuncture were all associated with improved scores on the Coma Recovery Scale-Revised (CRS-R). The mean difference (MD) ranged from 17.32 (95% CrI: 6.57 to 104.25) in the rTMS group to 3.56 (95% CrI: 0.61 to 40.45) in the acupuncture group. According to the Surface Under the Cumulative Ranking Curve (SUCRA), rTMS was associated with the highest probability of being the most effective intervention. In subgroup analyses, among patients with minimally conscious state (MCS), the MD ranged from 15.99 (95% CrI: 1.57 to 66.77) in the tDCS group to 9.72 (95% CrI: 2.07 to 61.04) in the MNS group, and among patients with unresponsive wakefulness syndrome (UWS), the MD ranged from 18.52 (95% CrI: 2.15 to 108.73) in the rTMS group to 4.12 (95% CrI: 0.25 to 69.30) in the acupuncture group. Conclusion: rTMS, tDCS, MNS, HBO, and acupuncture may improve CRS-R scores and promote consciousness recovery in patients with pDOC. Among these interventions, tDCS may be associated with more favorable effects in patients with MCS, whereas rTMS appears to be more beneficial for those with UWS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.