Evidence map›Paper›PMID 42211616›Full record

ReviewCureus2026

Efficacy and Safety of Limosilactobacillus reuteri DSM 17938 in Infantile Colic: A Narrative Review From Pathogenesis to Clinical Practice.

Kimberly Carvajal Méndez, Ana Gabriela Álvarez Barrientos, Freddy Gutiérrez Rivera, Daniel Aragón Leiva, Dennis Ulate Fuentes

Abstract readReview
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kimberly Carvajal MéndezFaculty of Medicine, Universidad de Costa Rica, San José, CRI.
Ana Gabriela Álvarez BarrientosFaculty of Medicine, Universidad de Iberoamerica (UNIBE), San José, CRI.
Freddy Gutiérrez RiveraFaculty of Medicine, Universidad de Costa Rica, San José, CRI.
Daniel Aragón LeivaFaculty of Medicine, Universidad de Costa Rica, San José, CRI.
Dennis Ulate FuentesFaculty of Medicine, Universidad Latina, San José, CRI.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infantile colic is one of the most common functional gastrointestinal disorders, affecting approximately 20% of infants worldwide. Characterized by paroxysmal episodes of inconsolable crying and fussing without an obvious cause, the condition imposes a significant psychosocial burden on the family unit, acting as a primary trigger for maternal postpartum depression, parental exhaustion, and premature cessation of breastfeeding. Despite its prevalence, traditional management in primary care remains heterogeneous and often ineffective, leaving a substantial therapeutic gap. Emerging research has identified gut dysbiosis as a cornerstone of its pathogenesis, where an imbalance in early microbial colonization, characterized by reduced diversity and a higher prevalence of gas-producing coliforms, triggers intestinal inflammation and visceral hypersensitivity through the gut-brain axis. This narrative review synthesizes the current clinical evidence regarding the efficacy and safety of

Indexed as

dsm 17938dysbiosisfgidsfunctional gastrointestinal disordersgastrointestinal microbiomeinfantile coliclimosilactobacillus reuteriprobiotics

Identifiers

PMID42211616
PMCPMC13215626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.