Evidence map›Paper›PMID 42212002›Full record

ArticleFrontiers in aging neuroscience2026

From muscle to brain: the mediating effect of vitamin D in the relationship between muscle loss and cognitive function in Alzheimer's disease.

Xiaoting Ma, Linlin Yao, Fangbo Li, Chong Cui, Erlei Wang, Caishan Wang, Ping Zhao, Xiaofen Weng, Chunfeng Liu, Shanwen Liu and 1 more

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoting MaDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Linlin YaoDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Fangbo LiDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chong CuiDepartment of Imaging, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Erlei WangDepartment of Imaging, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Caishan WangDepartment of Ultrasound Imaging, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Ping ZhaoDepartment of Ultrasound Imaging, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xiaofen WengDepartment of Geriatric Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Chunfeng LiuDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Shanwen LiuDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hua HuDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the association among Vitamin D (VD), muscle loss and cognitive function, and further analyze the possible role of VD in the association between muscle loss and cognitive function in patients with Alzheimer's disease (AD). Methods: This cross-sectional study included 58 patients with AD (30 mild and 28 moderate) and 30 neurotypical controls (NC). Demographic data, neuropsychological tests, and serum VD levels were collected. Muscle loss related indicators, including both clinical macroscopic and morphological microstructural indicators, were measured. Results: The differences among 3 groups in different cognitive domains, muscle loss related indicators and serum VD levels were statistically significant ( Conclusion: VD level, muscle loss, and cognitive dysfunction are closely related, and VD partially mediated the association between muscle mass reduction and cognitive dysfunction in patients with AD. These preliminary findings highlight the importance of assessing muscle loss and VD deficiency, and suggest that targeted intervention may be a valuable management strategy for the AD population.

Indexed as

Alzheimer’s diseasecognitive functionmediating effectmuscle lossvitamin D

Identifiers

PMID42212002
PMCPMC13212239

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.