ReviewFrontiers in psychology2026
Renewal and reacquisition of substance-associated relapse.
Review in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renewal and reacquisition (R/R) of drug-seeking behaviors are key drivers of relapse in substance use disorders (SUDs). These processes emerge from interactions among learning, memory, and reward-related neural circuits that are engaged when individuals encounter drug-associated contexts, cues, stressors, or restored drug availability. Advances in animal models and experimental tools have improved our understanding of the neurobiological mechanisms that cause relapse, including how substance-associated memories are formed and retrieved, how context-dependent renewal happens after extinction or punishment-based interventions, and how substance seeking and taking restarts rapidly when reinforcement is restored. In this review, we synthesize evidence on behavioral, circuit-level and molecular processes that contribute to R/R across substances, highlighting translational and clinical parallels, and identifying mechanistic gaps that constrain intervention development. We conclude by outlining mechanism-informed strategies that integrate behavioral, pharmacological, and genetic interventions to strengthen the generalization (transference) and durability of extinction learning and memory updating, to reduce relapse vulnerability, particularly driven by R/R.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.