ArticleInfection and drug resistance2026
Root Cause Analysis for Outbreaks of Carbapenem-Resistant
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: Children in the pediatric intensive care unit (PICU) are inherently susceptible to multidrug-resistant (MDR) bacterial infections due to physiological vulnerabilities and clinical management-related factors. Such infections are prone to outbreaks and confer substantial harm. This study aims to investigate the etiologies of carbapenem-resistant Methods: A retrospective analysis was conducted on five cases (n=5) of MDR infection clusters admitted to the PICU of a large comprehensive hospital from January to February 2024. RCA was applied to identify underlying causes, develop targeted interventions, and evaluate their effectiveness. Results: From 31 January to 18 February 2024, four CRAB strains and three CRPA strains were detected among five patients (n = 5). Environmental sampling (145 specimens) revealed CRAB in four sites (crane tower, handwashing basin wall, healthcare workers' hands, and PDA devices) and CRPA in two sites (fiberoptic bronchoscopes and healthcare workers' hands). Post-intervention, no further MDR clusters were observed in 2024, indicating effective control. Conclusion: RCA facilitates systematic identification of root causes for MDR outbreaks, enabling targeted interventions to curb transmission and strengthen infection control practices.
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