ArticleIranian journal of basic medical sciences2026
Remote ischemic preconditioning protects heart via modulation of purinergic signaling and AMPK-mediated autophagy in rat model of ischemia reperfusion injury.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Remote ischemic preconditioning (RIPC) represents a non-invasive, clinically applicable conditioning technique that mitigates myocardial ischemia-reperfusion injury (MIRI). Among various molecular mediators, the adenosine A Materials and Methods: Prolonged ischemia of 30 min and sustained reperfusion of 120 min were given to isolated hearts of rats using the Langendorff perfusion system to induce MIRI. RIPC was elicited through four intermittent phases of 5-minute hind-limb ischemia and 5-minute reperfusion using a pressure cuff. The role of AA Results: IRI-induced myocardial damage was manifested by a substantial rise in infarct size, elevated levels of cardiac-specific markers, i.e., LDH-1, CK-MB, C-tPn-I, altered hemodynamic parameters (decreased HR, CFR, LVDP, RPP, +dp/dt Conclusion: These findings substantiate that RIPC exerts potent cardioprotective effects via activation of AA
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