ArticleClinical psychological science : a journal of the Association for Psychological Science2026
Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.
LiChen Dong, A Brooke Sasia, James J Li
Abstract read
In one paragraphArticle in Clinical psychological science : a journal of the Association for Psychological Science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
3 authors.
LiChen DongDepartment of Psychology, University of Wisconsin-Madison.
A Brooke SasiaDepartment of Psychology, University of Wisconsin-Madison.
James J LiDepartment of Psychology, University of Wisconsin-Madison.
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MWave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VII Core ProjectU01AG071448 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER · 2021 to 2026
$40.2MProject 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia ProjectU01AG071450 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HUMMER, ROBERT A · 2021 to 2025
$16.2MWaisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5MThe development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MUsing the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9MAdd Health: A Genotype and Phenotype Resource for the Global Scientific CommunityR01HD073342 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 2012 to 2016
$3.6MSocial Demographic Moderation of Genome Wide Associations for Body Mass IndexR01HD060726 · NICHD · UNIVERSITY OF COLORADO · PI BOARDMAN, JASON D, MCQUEEN, MATTHEW B · 2010 to 2014
$2.7MThe impact of early life adversity on brain network development in youthR01MH128371 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Rasmus Matthias Birn · 2022 to 2026
$1.9MIntegrating developmental and genomic approaches to identify early trajectories of eating and internalizing disorder symptomsR01MH134039 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nadia Micali, Jin Peng Szatkiewicz · 2024 to 2026
$1.6MNIAAA NIH HHS K02 AA018755NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA015416NIAAA NIH HHS U10 AA008401NIA NIH HHS U01 AG071448NIA NIH HHS U01 AG071450NICHD NIH HHS P01 HD031921NICHD NIH HHS P50 HD105353NICHD NIH HHS R01 HD060726NICHD NIH HHS R01 HD073342NIDA NIH HHS R01 DA050721NIMH NIH HHS R01 MH128371NIMH NIH HHS R01 MH134039
6 · The paper itselfAbstract
We investigate gene-environment interplay for the development of externalizing (EXT) behaviors in Add Health. Latent trajectories of substance use (SUB) and antisocial behaviors (ASB) spanning ages 13 to 41 were extracted in a prior study (Sasia et al., 2025). Adolescent psychosocial environments (i.e., supportive parenting, delinquent peer affiliation, school connectedness, and neighborhood connectedness) were modeled to moderate and mediate the effects of EXT polygenic scores (PGS) in predicting SUB and ASB trajectories in European (
Indexed as
developmentexternalizing behaviorgene-environment interplayindirect effectspolygenic scores
Identifiers
PMID42212239
PMCPMC13215388
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390