Evidence map›Paper›PMID 42212246›Full record

ArticlePrecision clinical medicine2026

Calming sterile inflammation in intervertebral disc degeneration: taurine disrupts mitochondria-cGAS-STING signaling via autophagy enhancement.

Shuangjia Zai, Huofeng Wu, Xuan You, Chen Liu, Zhaoyu Li, Benkui Hua, Chengyu Hou, Zhengguang Li, Liang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Precision clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuangjia ZaiDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.
Huofeng WuDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.
Xuan YouDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.
Chen LiuDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.
Zhaoyu LiDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.
Benkui HuaDepartment of Orthopedics, Northern Jiangsu People's Hospital, No. 98 Nantong West Road, Yangzhou 225001, China.
Chengyu HouDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.
Zhengguang LiDepartment of Orthopedics, Northern Jiangsu People's Hospital, No. 98 Nantong West Road, Yangzhou 225001, China.
Liang ZhangDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intervertebral disc degeneration (IVDD) is a major pathological process leading to low back pain, closely associated with the functional decline of nucleus pulposus progenitor cell (NPPC). The role of the cGAS-STING pathway in mediating DNA-sensing-associated inflammation and senescence in IVDD has not been fully elucidated. Methods: This study integrated genetics, computational biology, cellular experiments, and animal models to systematically investigate whether taurine (TAU) exerts protective effects by modulating this pathway. Results: Mendelian randomization analysis suggested a causal relationship between higher TAU levels and reduced risk of IVDD. Molecular docking and dynamics simulations demonstrated that TAU stably binds to cGAS and STING. In both degenerated human nucleus pulposus (NP) tissues and an H Conclusion: This study is the first to reveal that TAU mitigates IVDD through multi-targeted modulation of the "mitochondria-cGAS-STING" axis, providing a theoretical foundation for its translational application as a disease-modifying agent.

Indexed as

intervertebral disc degenerationmitochondrianucleus pulposus progenitor cellSTINGtaurine

Identifiers

PMID42212246
PMCPMC13213379

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.