ArticlePhysical chemistry chemical physics : PCCP2026
Combining photo-CIDNP and long-lived spin states enables high-contrast detection of weak protein-ligand interactions.
Article in Physical chemistry chemical physics : PCCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Photo chemically induced dynamic nuclear polarization (photo-CIDNP) and long-lived spin states (LLS) are two nuclear magnetic resonance (NMR) techniques that can be combined to achieve large signal enhancements and extended lifetimes of spin order, respectively, and their combination is useful for detecting biomolecular interactions. Here, we demonstrate that integrating photo-CIDNP hyperpolarization with LLS excitation through spin-lock induced crossing (SLIC) enables the highly sensitive detection of signals of ligands at micromolar concentrations. Using indole-3-propionic acid (IPA), we show that two of its CH
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