ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Diagnostic Value of Coagulation-Fibrinolysis Biomarkers for Metastasis in Lung, Ovarian, Breast, and Colorectal Cancers.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IntroductionDysregulation of the coagulation and fibrinolytic systems has been closely linked to cancer progression and metastasis. This study investigated whether the coagulation- and fibrinolysis-related biomarkers, TAT, PIC, TM, and tPAIC, are correlated with cancer metastasis.MethodsPlasma levels of TAT, PIC, TM, and tPAIC were measured in 240 treatment-naive patients with lung, ovarian, breast, or colorectal cancer and 120 healthy individuals. Participants were categorized into metastasis, non-metastasis and healthy groups based on clinical evaluation and imaging results. Statistical analysis and ROC curves were used to assess the performance of individual and combined biomarkers in detecting metastasis.ResultsAll four biomarkers were significantly elevated in patients with metastasis (
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