Evidence map›Paper›PMID 42212722›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Asymmetric Reductive Three-Component Annulation Reaction for Constructing Fused N-Heterocycles With Contiguous Stereogenic Centers.

Guang-Peng Lu, Huan-Feng Jiang, Cheng-Gang Ci, Pierre H Dixneuf, Min Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guang-Peng LuKey Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, P. R. China.
Huan-Feng JiangKey Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0002-4355-0294
Cheng-Gang CiGuizhou Provincial Key Laboratory of Green Catalysis and Materials for Resource Conversion, Department of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun, P. R. China.
Pierre H DixneufUniversity of Rennes, Rennes, France.
Min ZhangKey Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0002-7023-8781

Funding

Central Guidance on Local Science and Technology Development Fund of Guizhou Province 2025-043National Natural Science Foundation of China 22163007National Natural Science Foundation of China 22471080Natural Science Foundation of Guangdong Province 2025A1515012079Natural Science Foundation of Guizhou Province KJZY[2025]073Natural Science Foundation of Guizhou Province ZSYS[2025]033
6 · The paper itself

Abstract

The development of efficient methods for the diverse synthesis of optically active fused N-heterocycles is vital for advancing medicinal chemistry. Hydrodearomative annulation of weakly reactive azaarenes presents a promising yet challenging strategy to fulfil such a synthetic purpose. Herein, we report a reductive three-component reaction for the construction of fused N-heterocycles with contiguous quaternary and tertiary carbon stereocenters, enabled by a simple chiral phosphoric acid/PhSiH

Indexed as

asymmetric annulation reactionchiral phosphoric acid catalysiscontiguous stereocentersfused N‐heterocycleshydrodearomatization

Identifiers

PMID42212722
PMCPMC13411506

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.