Evidence map›Paper›PMID 42212993›Full record

ArticleJACC. Advances2026

Genetic Variants Associated With Nonpulmonary Vein Triggers of Atrial Fibrillation: A Genome-Wide Association Study.

Sho Okamura, Motoki Furutani, Mika Nakashima, Noboru Oda, Takehito Tokuyama, Yousaku Okubo, Shunsuke Miyauchi, Shogo Miyamoto, Naoto Oguri, Takumi Sakai and 8 more

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In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sho OkamuraDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Motoki FurutaniDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.
Mika NakashimaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Noboru OdaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Takehito TokuyamaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Yousaku OkuboDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shunsuke MiyauchiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shogo MiyamotoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Naoto OguriDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Takumi SakaiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Naoki IshibashiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Junji MaedaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shunsuke IshidaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shumpei NiidaResearch Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.
Kouichi OzakiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Daichi ShigemizuDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.
Hidenori OchiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan; Department of Health Management, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japan; Department of Gastroenterology and Metabolism, Biomedical Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Yukiko NakanoDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan. Electronic address: nakanoy@hiroshima-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) originating from non-pulmonary vein (non-PV) foci is a major cause of postablation recurrence; however, its underlying mechanisms remain poorly understood.

objectivesThe purpose of this study was to identify genetic variants and electrophysiological features associated with AF originating from non-PV foci.

methodsWe performed a genome-wide association study in 1,091 patients with paroxysmal AF undergoing first catheter ablation. AF triggers were classified into PV or non-PV groups based on standardized electrophysiological testing with isoproterenol provocation. AF originating from the posterior wall of the left atrium, including the PV antrum, was categorized into the PV group. Associations between genetic variants and non-PV AF triggers were assessed and validated in an independent cohort (n = 371).

resultsNon-PV AF triggers were documented in 126 of 1,010 patients (12.5%) in the discovery cohort and 37 of 346 patients (10.7%) in the replication cohort. The variant rs117203318 (T>C) showed the strongest association with non-PV AF triggers (P = 4.65 × 10

conclusionsThe rs117203318 variant, near genes associated with myocardial fibrosis and cellular stress responses, is associated with AF originating from non-PV foci. These findings suggest that there may be distinct substrates for non-PV AF and this could inform strategies to improve ablation outcomes.

Indexed as

atrial fibrillationgenetic variantnonpulmonary vein foci

Identifiers

PMID42212993
PMCPMC13308242

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.