Evidence map›Paper›PMID 42213124›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Comparison of PET imaging of [18F]F-FAPI and [18F]F-FDG for diagnosis of suspected lymph node metastases in penile squamous cell carcinoma: a prospective pilot study.

Wei Ouyang, Xiaopeng Tong, Weibin Hou, Chunqing Zhou, Hua Fu, Jianye Liu, Qi Wang, Zhizhong Liu, Kun Yao, Xiang Li and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. How organs react under fasting or glucose-insulin status: a self-controlled study usingEuropean journal of nuclear medicine and molecular imaging · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei Ouyang *Department of Urology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Xiaopeng Tong *Department of Nuclear Medicine, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Weibin HouDepartment of Urology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Chunqing ZhouDepartment of Nuclear Medicine, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Hua FuDepartment of Pathology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Jianye LiuDepartment of Urology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Qi WangDepartment of Oncology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Zhizhong LiuDepartment of Urology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medical, Central South University, Changsha, 410013, Hunan, China.
Kun YaoDepartment of Urology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China.
Xiang LiDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Min ZhaoDepartment of Nuclear Medicine, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China. mzhao1981@csu.edu.cn.
Long WangDepartment of Urology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China. wanglong@csu.edu.cn.ORCID 0000-0003-4583-2428

Funding

The Furong Scholars Program of Hunan Province and the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South Universit No.BJ202504The Furong Scholars Program of Hunan Province and the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University BJ202505the Graduate Innovation Project of Central South University NO.2024XQLH112The Hunan Provincial Natural Science Foundation No. 2024JJ8123The National Natural Science Foundation of China No.82472029
6 · The paper itself

Abstract

purposeTo evaluate the potential value of [18F]F-FAPI PET/CT for detecting inguinal lymph node (ILN) metastases in locally advanced penile squamous cell carcinoma (PSCC) and to compare the results with those of [18F]F-FDG PET/CT.

methodsIn this prospective pilot study, 25 patients with histologically confirmed PSCC underwent both [18F]F-FAPI and [18F]F-FDG PET/CT followed by radical ILN dissection within 30 days. Diagnostic performance was assessed using postoperative histopathology as the reference. Semi-quantitative parameters (SUVmax, SUVmean, tumor-to-background ratio (TBR)) were analyzed, and immunohistochemical staining for FAP and GLUT1 was performed on resected lymph nodes to assess correlations with PET-derived metrics.

resultsAmong 25 evaluable patients, 12 (48%) had pathologically confirmed lymph node metastases. On a patient-based analysis showed [18F]F-FAPI PET/CT achieved 100% accuracy in N-staging, compared to 72% for [18F]F-FDG PET/CT. On a lesion-based analysis, a total of 447 lymph nodes were dissected, of which 27 were confirmed as metastases. The sensitivity, specificity, positive predictive value, and accuracy for [18F]F-FDG vs. [18F]F-FAPI PET/CT were as follows: sensitivity, 0.89 (95% CI: 0.71-0.97) vs. 0.96 (95% CI: 0.81-1.00); specificity, 0.93 (95% CI: 0.90-0.95) vs. 1.00 (95% CI: 0.99-1.00); PPV, 0.44 (95% CI: 0.35-0.53) vs. 1.00 (95%CI: 0.87-1.00); and accuracy, 92.2% vs. 99.8%, respectively. Metastatic lymph nodes exhibited significantly higher SUVmax, SUVmean, and TBR than benign nodes, with [18F]F-FAPI demonstrating superior discriminative ability. Immunohistochemical analysis revealed markedly elevated expression of both FAP and GLUT1 in metastatic nodes than in benign nodes, with FAP upregulation being more pronounced. FAPI uptake correlated positively with FAP expression, whereas FDG uptake correlated positively with GLUT1 expression.

conclusion[18F]F-FAPI PET/CT demonstrates promising diagnostic performance in detecting ILN metastases in patients with PSCC compared to [18F]F-FDG. This modality holds potential value in refining patient selection for inguinal lymph node dissection and reducing unnecessary surgical morbidity.

trial registrationChiCTR2400085605. https://www.chictr.org.cn .

Indexed as

Carcinoma, Squamous CellFluorodeoxyglucose F18Penile NeoplasmsPositron Emission Tomography Computed TomographyAdultAgedEndopeptidasesFibroblast Activation Protein AlphaHumansLymphatic MetastasisMaleMiddle AgedPilot ProjectsProspective StudiesRadiopharmaceuticalsEndopeptidasesFibroblast Activation Protein AlphaFluorodeoxyglucose F18RadiopharmaceuticalsFibroblast activation protein inhibitorInguinal lymph nodes metastasisMolecular imagingPenile squamous cell carcinomaPET/CT

Identifiers

PMID42213124

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.