Evidence map›Paper›PMID 42213129›Full record

ArticleEuropean journal of applied physiology2026

The impact of a 12-week high-intensity interval training program on popliteal vascular responses to prolonged sitting.

Haoxuan Liu, Sophie E Rayner, Beverly D Schwartz, Yanlin Wu, Jennifer L Petterson, Myles W O'Brien, Derek Stephen Kimmerly

Abstract read
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In one paragraph

Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haoxuan LiuAutonomic Cardiovascular Control and Exercise Laboratory, Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.
Sophie E RaynerAutonomic Cardiovascular Control and Exercise Laboratory, Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.
Beverly D SchwartzAutonomic Cardiovascular Control and Exercise Laboratory, Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.
Yanlin WuAutonomic Cardiovascular Control and Exercise Laboratory, Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.
Jennifer L PettersonAutonomic Cardiovascular Control and Exercise Laboratory, Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada.
Myles W O'BrienDepartment of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
Derek Stephen KimmerlyAutonomic Cardiovascular Control and Exercise Laboratory, Division of Kinesiology, School of Health and Human Performance, Faculty of Health, Dalhousie University, 6230 South Street, Halifax, NS, B3H 4R2, Canada. dskimmerly@dal.ca.ORCID http://orcid.org/0000-0002-3462-8037

Funding

Nova Scotia Health Research Foundation Nova Scotia Health Research Foundation
6 · The paper itself

Abstract

purposeWe examined the impact that 12-weeks of high-intensity interval training (HIIT) had on aerobic fitness and popliteal artery endothelium-dependent (flow-mediated dilation, FMD) and -independent dilatory function (nitroglycerin-mediated dilation, NMD) in response to an acute bout of prolonged sitting.

methodsTwenty-one healthy adults were assigned to HIIT (n = 11, 7♀, 24 ± 8 years) or Control groups (n = 10, 6♀, 22 ± 1 years). Popliteal artery FMD response to 5-min distal cuff occlusion and NMD were assessed via duplex ultrasonography before and after ~ 2-h of uninterrupted sitting. Peak oxygen consumption (relative V̇O

resultsThe 12-week HIIT intervention improved relative V̇O

conclusionsA 12-week HIIT intervention improved aerobic fitness but did not provide protection against prolonged sitting-induced impairments in popliteal artery endothelial function or vascular smooth cell function.

Indexed as

High-Intensity Interval TrainingPopliteal ArterySitting PositionAdultEndothelium, VascularFemaleHumansMaleOxygen ConsumptionVasodilationYoung AdultAerobic trainingCardiorespiratory fitnessEndothelial functionSedentary posture

Identifiers

PMID42213129

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.