Evidence map›Paper›PMID 42213645›Full record

ArticleBrain and behavior2026

Sex- and Region-Specific Glial Reactivity in Hyperthyroid Mice Lacks Correlation With the Noncognitive and Non-Depressive-Like Behavioral Alterations.

Qianqian Xue, Zefang Lin, Yaofeng Wang, Xiuting Lin, Yun Yang, Chao Wang, Yuhong Ye, Weibing Miao

Abstract read
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In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qianqian XueDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0000-6609-9857
Zefang LinDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0006-0933-4332
Yaofeng WangDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0004-3963-3187
Xiuting LinDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0001-6738-4761
Yun YangDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0002-7628-0451
Chao WangDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0003-0554-8948
Yuhong YeDepartment of Pathology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0000-0003-1857-9236
Weibing MiaoDepartment of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.ORCID https://orcid.org/0000-0002-0058-4953

Funding

Fujian Provincial Clinical Key Specialty Construction Project 2023SZDZK-HYXKNational Natural Science Foundation of China 82472012Natural Science Foundation of Fujian Province 2023J01590Startup Fund for Scientific Research of Fujian Medical University 2022QH1057
6 · The paper itself

Abstract

backgroundGlial reactivity is implicated in hyperthyroidism-associated cognitive and psychiatric disorders, yet in vivo imaging evidence of glial reactivity in hyperthyroidism remains to be elucidated. This study aimed to detect hyperthyroidism-induced glial reactivity using

methodsC57BL/6J mice were randomly divided into hyperthyroid (T4) and control groups.

resultsCortical and hippocampal IBA-1 and GFAP densities were significantly elevated in T4 mice, with sex-dependent GFAP expression (male higher in cortex, female higher in hippocampus). PET/CT showed that T4 markedly increased SUV in striatum, thalamus, hypothalamus, brainstem, and midbrain in female mice only, while in cortex, hippocampus, and amygdala, T4 increased SUV in both sexes. Hyperthyroid mice did not show cognitive decline or depressive-like behaviors. Instead, male T4 mice displayed shortened immobility time, and both sexes showed increased platform crossings and greater target quadrant distance. No significant associations were found between glial reactivity measures and behavioral outcomes.

conclusionsHyperthyroidism induces sex- and region-specific glial reactivity detected by

Indexed as

Behavior, AnimalBrainHyperthyroidismNeurogliaAnimalsCalcium-Binding ProteinsDepressionFemaleGlial Fibrillary Acidic ProteinHippocampusMaleMiceMice, Inbred C57BLMicrofilament ProteinsPositron Emission Tomography Computed TomographyAif1 protein, mouseCalcium-Binding ProteinsGlial Fibrillary Acidic ProteinMicrofilament Proteinsastrocytescognitivedepressionglial reactivityhyperthyroidismmicrogliaPET/CT

Identifiers

PMID42213645
PMCPMC13240366

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.