Observational studyDeutsches Arzteblatt international2026
The Incidence, Pathogen Spectrum, and Resistance Profile of Pyogenic Spondylodiscitis: A Nationwide Retrospective Evaluation of G-DRG Data.
Observational study in Deutsches Arzteblatt international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of the spinal infection pyogenic spondylodiscitis is rising, particularly in the aging, multimorbid segment of the population. The goal of this study was to analyze nationwide trends in the epidemiology, pathogen spectrum, and antimicrobial resistance profile of this disease in Germany over the period 2005–2023.
methodsAll hospital discharges were analyzed retrospectively using nationwide German Diagnosis Related Groups (G-DRG) data. Hospitalizations with a primary ICD-10-GM diagnosis of spinal osteomyelitis, pyogenic intervertebral disc infection, or discitis, not otherwise specified (M46.2*, M46.3*, M46.4*) were included for analysis. The age-adjusted incidence was calculated using population data from the Federal Statistical Office. Pathogen determinations and resistance phenotypes were ascertained from supplementary pathogen codes.
resultsA total of 151 544 cases were identified. Over the study period, the age-adjusted incidence doubled (from 5.41 to 10.02 cases per 100 000 persons), the patients’ mean age increased from 65.8 to 72.2 years, and the proportion of patients aged 70 years or more rose (from 42.6% to 62.3%). The mean length of hospital stay decreased, while in-hospital mortality doubled (from 3.25% to 6.79%). At the same time, the rate of pathogen determination improved. The proportion of
conclusionIn Germany, pyogenic spondylodiscitis mainly affects older patients, and the associated in-hospital mortality is rising. Changes in the pathogen spectrum and in resistance patterns indicate the need for corresponding adjustments to empirical treatment regimens.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.