ArticleMolecular & cellular proteomics : MCP2026
π-SeqOmics: A Sequential Workflow for Genomic, Transcriptomic, Proteomic, and Phosphoproteomic Profiling From Biopsy-Scale Samples.
Article in Molecular & cellular proteomics : MCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Comprehensive multiomics profiling from a single limited specimen remains challenging, as current extraction methods are difficult to standardize and often compromise balanced recovery of nucleic acids and proteins. Here, we developed π-SeqOmics, a phenol-free workflow established through systematic benchmarking for the sequential isolation of DNA, RNA, and proteins from a single specimen, enabling integrated genomic, transcriptomic, proteomic, and phosphoproteomic analyses. Compared with conventional extraction and in-solution digestion workflows, π-SeqOmics achieves comparable proteomic and phosphoproteomic depth and reproducibility while preserving high-quality DNA and RNA for sequencing. The workflow performed robustly across a wide input range (5 × 10
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