Evidence map›Paper›PMID 42214760›Full record

ArticleNeurotoxicology2026

Acute wood smoke exposure is associated with cell-specific hippocampal transcriptomic responses in an accelerated ovarian failure mouse model.

Sydnee J Yazzie, Mijung Oh, Eunju Lim, Onamma Edeh, Edward Barr, Ting Jiang, Tou Yia Vue, Shuguang Leng, Eric Prossnitz, Robert Miller and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sydnee J YazzieDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Mijung OhDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Eunju LimDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Onamma EdehDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Edward BarrDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA.
Ting JiangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA.
Tou Yia VueDepartment of Neurosciences, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Shuguang LengDepartment of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Eric ProssnitzDivision of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
Robert MillerCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA.
Kartika WardhaniMaterials Physics and Applications Division, Center for Integrated Nanotechnologies (MPA-CINT), Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Connor DixsonDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Jennifer GilletteDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Katherine E ZychowskiDepartment of Pathology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: kzychowski@salud.unm.edu.

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Pilot Project CoreP30ES032755 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BLOSSOM, SARAH J · 2022 to 2025
$5.2M
Initiative to Maximize Student Diversity at the University of New Mexico Health Sciences Center 2021T32GM144834 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Judy Lin Cannon, Bryce C Chackerian · 2022 to 2026
$2.7M
Systemic Implications and Novel Mechanisms of Circulating Extracellular Vesicles Following Inhaled ExposuresR01ES033981 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Katherine Zychowski · 2023 to 2026
$2.1M
RapifleX MALDI-TOF/TOF Mass SpectrometerS10OD032175 · OD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI FENG, CHANGJIAN · 2023 to 2023
$600k
NCI NIH HHS P30 CA118100NIEHS NIH HHS P30 ES032755NIEHS NIH HHS R01 ES033981NIGMS NIH HHS T32 GM144834NIH HHS S10 OD032175
6 · The paper itself

Abstract

backgroundWildfire events are increasing in frequency and intensity, and aging individuals demonstrate heightened biological susceptibility to air pollution exposures including increased risk of neurological sequelae. Declining ovarian hormones levels that occur with aging in females along with associated systemic physiological and inflammatory changes may contribute to increased cerebral vulnerability to air pollution, representing a potential but underexplored mechanism. Menopause and the menopausal transition represent a period of profound physiological change that affects cardiovascular, neurological, and immune health.

methodsWe tested whether peri-menopausal-like hormonal status amplifies hippocampal responses to acute wood smoke (WS) using an ovary-intact, 4-vinylcyclohexene diepoxide (VCD) model of moderate accelerated ovarian failure (AOF) in female C57BL/6 mice. Animals were exposed to HEPA-filtered air (FA) or WS for 4 h/day over 2 consecutive days (∼0.5 mg/m³). Exposure characterization confirmed a complex mixture of combustion products with significant levels of both trace metals and gas release during WS exposure.

resultsSpatial transcriptomics (10x Visium; n = 4 sections/group) with automated cell-type annotation identified astrocytes, GABAergic and glutamatergic neurons, oligodendrocytes, revealed cell type-specific transcriptional alterations following WS exposure. Distinct transcriptional patterns were observed across all identified neuronal and glial cell populations.

conclusionTogether, these findings define a cell-type specific transcriptomic framework describing how WS exposure and ovarian hormone decline interact to influence hippocampal responses and identify potential cellular pathways relevant to hippocampal vulnerability.

Indexed as

HippocampusSmokeTranscriptomeWoodAnimalsCyclohexenesDisease Models, AnimalFemaleMiceMice, Inbred C57BLVinyl Compounds4-vinyl-1-cyclohexene dioxideCyclohexenesSmokeVinyl CompoundsGlial cellsHippocampusHormone declineNeuroinflammationNeuronsOvarianSpatial transcriptomics

Identifiers

PMID42214760
PMCPMC13292828

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.