Evidence map›Paper›PMID 42215285›Full record

ArticleCell proliferation2026

A Specific tRNA Half, 3'tiRNA-GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf-Mediated Endoplasmic Reticulum Stress.

Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lixin ZhangCollege of Medical Laboratory Science and Technology, Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Xiaoyu GuanCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Xiangrui ZhuInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, Xiamen, P. R. China.
Yingying HaoCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Ya XuCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Hao YuanCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Danni GaoCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Hongxia DuCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Jiayu LiCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Weiwei CaoCollege of Pharmacy, Harbin Medical University, Daqing Campus, Daqing, P. R. China.
Cui MaInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, Xiamen, P. R. China.
Xiaoying WangCentral Laboratory of Harbin Medical University, Daqing Campus, Daqing, P. R. China.ORCID https://orcid.org/0000-0002-1008-9155

Funding

Fundamental Research Funds for the Provincial Universities JFQN202301Guidance project of Daqing city zdy-2025-108Heilongjiang Provincial Natural Science Foundation of China LH2024H029High-quality Development Science and Technology Program of Xiamen Municipal Health Commission 2024GZL-CX05National Natural Science Foundation of China 32400949National Natural Science Foundation of China 82400062National Natural Science Foundation of China 82570079Science and Technology Project of the Health Commission of Fujian Province 2025CXAO63
6 · The paper itself

Abstract

Pulmonary artery smooth muscle cell (PASMC) proliferation is a hallmark of the pathogenesis of hypoxic pulmonary hypertension (PH), and endoplasmic reticulum stress (ERS) plays a crucial role. Many studies have implicated that tRNA-derived fragment, tiRNAs, in a variety of biological processes, but their roles in hypoxia-induced PASMC ERS and proliferation have not been investigated. In this study, we identified a significantly upregulated 3'tiRNA-GlyGCC in hypoxic mouse lung tissues using Arraystar small RNA microarray analysis. Functional assays, including CCK8, EdU incorporation, Western blot, and immunofluorescence, demonstrated that inhibition of 3'tiRNA-GlyGCC reversed hypoxia-induced ERS and proliferation in PASMCs. Mechanistically, 3'tiRNA-GlyGCC interacts with the eukaryotic translation elongation factor 1 alpha 1 (Eef1a1) protein and reduces the binding capacity between Eef1a1 and myelin regulatory factor (Myrf) mRNA, leading to decreased stability of Myrf mRNA. Additionally, 3'tiRNA-GlyGCC targets Myrf mRNA and inhibits its expression. We further verified that angiogenin (Ang) mediated the biogenesis of 3'tiRNA-GlyGCC under hypoxic conditions. Collectively, these findings highlight a novel mechanism underlying PASMC ERS and proliferation and suggest that 3'tiRNA-GlyGCC could serve as a potential therapeutic target for hypoxic PH.

Indexed as

3′tiRNA‐GlyGCCendoplasmic reticulum stressproliferationpulmonary artery smooth muscle cellpulmonary hypertension

Identifiers

PMID42215285
PMCPMC13326036

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.