Evidence map›Paper›PMID 42215556›Full record

ArticleScientific reports2026

Long-term loss of TGF-β signaling in smooth muscle cells of aged adult mice disrupts proximal aortic wall structure and homeostasis.

Chloe Y Lee, Elizabeth F Johnston, Natalie S Lim, David A Dichek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chloe Y LeeDepartment of Medicine, University of Washington School of Medicine, 1959 NE Pacific Street Box, Seattle, WA, 357710, USA. ylee6625@uw.edu.
Elizabeth F JohnstonDepartment of Medicine, University of Washington School of Medicine, 1959 NE Pacific Street Box, Seattle, WA, 357710, USA.
Natalie S LimDepartment of Medicine, University of Washington School of Medicine, 1959 NE Pacific Street Box, Seattle, WA, 357710, USA.
David A DichekDepartment of Medicine, University of Washington School of Medicine, 1959 NE Pacific Street Box, Seattle, WA, 357710, USA.

Funding

Roles of SMC TGF-beta Signaling in Aortic Health and Aneurysm FormationR01HL116612 · NHLBI · UNIVERSITY OF WASHINGTON · PI DICHEK, DAVID A · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL116612NIH HHS R01HL116612
6 · The paper itself

Abstract

Roles of transforming growth factor β (TGF-β) signaling in smooth muscle cells (SMC) of the adult vasculature remain unclear. In this study, we investigate long-term effects of SMC-specific loss of TGF-β signaling in the aortas of adult mice. Eleven-month-old mice with SMC-specific Cre allele (Acta2-CreER

Indexed as

AgingAortaHomeostasisMyocytes, Smooth MuscleReceptor, Transforming Growth Factor-beta Type IISignal TransductionTransforming Growth Factor betaAnimalsFemaleMaleMiceMuscle, Smooth, VascularReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseTransforming Growth Factor betaAortaExtracellular matrixGenetic techniquesGrowth factorSmooth muscle cell

Identifiers

PMID42215556
PMCPMC13454599

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.