ArticleBMC pediatrics2026
Low expression of miR-126 constitutes a risk factor for perioperative respiratory adverse events among pediatric patients under general anesthesia.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aims to investigate the diagnostic value of miR-126 in Perioperative respiratory adverse events (PRAEs).
methodsThis study included 228 pediatric patients undergoing anesthesia and surgery, who were divided into two groups based on the occurrence of PRAEs. RT-qPCR was used to detect miR-126 levels, the CCK-8 assay was employed to evaluate cell proliferation capacity, and ELISA kits were utilized to measure TNF-α, IL-6, and IL-13 concentrations. The diagnostic value of miR-126 was assessed through receiver operating characteristic curve analysis.
resultsmiR-126 is significantly downregulated in the serum of children with PAREs. Low expression of miR-126 is one of the risk factors for PRAEs occurrence. miR-126 level shows a negative correlation with the inflammatory levels in children with PRAEs. Overexpression of miR-126 promotes cell proliferation activity.
conclusionmiR-126 may contribute to the suppression of PRAEs by regulating proliferation and inflammatory responses in BEAS-2B cells and may serve as a diagnostic biomarker.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.