ArticleBMC psychiatry2026
Treatment-related topological reorganization of the structural connectome in major depressive disorder with suicidal ideation.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundMajor depressive disorder with suicidal ideation (MDD-SI) is associated with a high risk of mortality. The specific longitudinal alterations in brain structural networks associated with SI remain unclear. We aimed to identify treatment-related topological reorganization in patients with MDD, with and without SI.
methodsThis longitudinal study leveraged graph theory and structural MRI to analyze brain network changes in 101 MDD patients (66 MDD-SI, 35 MDD-nSI) and 41 healthy controls (HC). Network properties were evaluated before and after 2 weeks of clinical treatment, with global and nodal metrics calculated to track topological reorganization. Subsequently, group × time interaction analyses were conducted to characterize treatment-specific trajectories of brain network evolution.
resultsWe identified SI-specific structural connectome alterations, characterized by increased network regularization and topological deficits in the posterior cingulate gyrus (PCG), insula, and hippocampus. Longitudinal analysis revealed that nodal centrality in the PCG and insula was significantly associated with SI severity. Crucially, a significant longitudinal interaction effect was observed in the PCG.
conclusionOur findings underscore the important role of the PCG in the structural network recovery of MDD-SI. The topological changes of the PCG may provide insight into the neurobiological mechanisms underlying suicide-related pathophysiology and treatment response in MDD-SI.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.