Trial reportCancer medicine2026
A Personalised and Gamified Digital Decision Aid for Colorectal Cancer Screening: A Randomised Controlled Pilot Study.
Trial report in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07269028 (Personalised and Gamification-based Decision Aid), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalised and Gamification-based Decision Aid (DA): a Randomized Controlled Pilot Study About Colorectal Cancer (CRC) Screening
Who cites it
2 citing papers in PubMed.
- A Personalised and Gamified Digital Decision Aid for Colorectal Cancer Screening: A Randomised Controlled Pilot Study.Cancer medicine · 2026Trial
- Correction to 'A Personalised and Gamified Digital Decision Aid for Colorectal Cancer Screening: A Randomised Controlled Pilot Study'.Cancer medicine · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
backgroundColorectal cancer (CRC) is the second leading cause of tumour-related mortality worldwide, accounting for approximately 903,000 deaths annually. Despite the proven effectiveness of population-based screening in reducing mortality, participation rates remain suboptimal, hindered by cognitive, psychological, and socioeconomic barriers.
objectiveThis study assessed the effectiveness of the PREVenGO smartphone application, a digital decision aid (DA) incorporating personalisation and gamification elements, in supporting informed decision-making and adherence to CRC screening.
methodsDA-CRC is a two-arm randomised controlled pilot trial. Individuals born in 1973-1974 and invited for the first time to the CRC screening programme by the Local Health Authority of Brescia (Northern Italy) were eligible. Invitation letters included instructions to download the PREVenGO app, which randomised participants into intervention or control arms. The intervention app integrated questionnaires on family history, prevention knowledge, and locus of control (LoC), together with gamified features and rewards, while the control version provided static educational material. Both groups received follow-up notifications at 3 (T1) and 6 months (T2).
resultsAmong those invited, 1% (n = 248) downloaded the app and completed onboarding. Follow-up retention was limited: only 18 participants (7.3%) completed the 3-month questionnaire (T1) and 1 (0.4%) the 6-month assessment (T2). The overall faecal occult blood test (FOBT) screening uptake was 86.7% (n = 215), with comparable rates in both arms (control: 84.3%, n = 102; intervention: 89.0%, n = 113; p = 0.278). Only 17% (n = 43) of participants met all Marteau framework criteria for informed choice, with critical knowledge gaps, particularly regarding overdiagnosis, false positives, and absolute screening benefit.
conclusionsPreliminary findings suggest that a digital DA with personalised and gamified content may enhance CRC screening uptake and partially support informed choice. Larger, multisite studies are warranted to evaluate scalability, inclusivity, and long-term effectiveness in population-based cancer prevention. CLINICAL REGISTRATION: ClinicalTrials.gov RCT n. NCT07269028. (https://clinicaltrials.gov/study/NCT07269028?term=NCT07269028&rank=1).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.