Evidence map›Paper›PMID 42216548›Full record

ReviewFrontiers in bioscience (Landmark edition)2026

Molecular Mechanisms of Manganese Oxide Nanoparticles Toxicity in Brain and Other Tissues: An Overview.

Michael Aschner, Anatoly V Skalny, Svetlana V Notova, Margarita N Tinkova, Rongzhu Lu, Andrey A Skalny, Abel Santamaria, Ji-Chang Zhou, Alexey A Tinkov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Anatoly V SkalnyCenter of Bioelementology and Human Ecology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Svetlana V NotovaLaboratory of Metallomics, Institute of Bioelementology, Orenburg State University, 460018 Orenburg, Russia.
Margarita N TinkovaOutpatient Department, Orenburg Central District Hospital, 460008 Orenburg, Russia.
Rongzhu LuDepartment of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, 212013 Zhenjiang, Jiangsu, China.
Andrey A SkalnyDepartment of Medical Elementology, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Abel SantamariaLaboratorio de Nanotecnología y Nanomedicina, Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, and Facultad de Ciencias, Universidad Nacional Autónoma de México, 04960 Mexico City, Mexico.
Ji-Chang ZhouSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 518107 Shenzhen, Guangdong, China.
Alexey A TinkovCenter of Bioelementology and Human Ecology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

Funding

Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
NIEHS NIH HHS R01 ES010563Russian Ministry of Science and Higher Education 075-15-2024-550
6 · The paper itself

Abstract

The use of manganese oxide nanoparticles (MnO

Indexed as

BrainManganese CompoundsMetal NanoparticlesNanoparticlesOxidesAnimalsHumansReactive Oxygen SpeciesManganese Compoundsmanganese oxideOxidesReactive Oxygen Speciesbrainmanganesenanomedicinenanoparticlestoxicity

Identifiers

PMID42216548
PMCPMC13240672

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.