Evidence map›Paper›PMID 42216628›Full record

ArticleBehavioural neurology2026

Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.

Devon K Grey, Elizabeth S Davis, Adam M Goodman, Juliann B Purcell, Heather E Dark, Nathaniel G Harnett, Anudeep Bolaram, Cameryn T Eickstead, Hayden C Cook, Sylvie Mrug and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Behavioural neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Devon K GreyDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0001-9036-6361
Elizabeth S DavisDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0002-6480-2083
Adam M GoodmanDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0002-7550-679X
Juliann B PurcellDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0003-3024-3313
Heather E DarkDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0001-7194-3637
Nathaniel G HarnettDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0001-5346-2012
Anudeep BolaramDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0003-2336-7393
Cameryn T EicksteadDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0009-0007-3913-4849
Hayden C CookDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0009-0002-8325-2002
Sylvie MrugDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0001-5426-8713
David C KnightDepartment of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA, uab.edu.ORCID https://orcid.org/0000-0002-1094-801X

Funding

NIH HHS R01MH098348
6 · The paper itself

Abstract

Black individuals are disproportionately exposed to adverse childhood experiences (ACEs) in comparison to White individuals, including greater violence exposure, neighborhood disadvantage, and poverty. Neural circuitry that includes the amygdala, hippocampus, prefrontal cortex (ventromedial, dorsomedial, and dorsolateral), and inferior parietal lobule support stress-related emotional processes. ACEs may modify emotion-related activity within these brain regions, which, in turn, may modulate emotional behavior. However, the extent to which ACEs underlie race-related differences in emotional function remains to be determined. Therefore, this study investigated whether stress-elicited brain activity varies with race-related differences in ACEs. Functional magnetic resonance imaging (fMRI) data from 301 Black and White participants were acquired during the Montreal Imaging Stress Task. Violence exposure, neighborhood disadvantage, and family income were measured during adolescence to assess ACEs, whereas stress-elicited brain function was assessed in emerging adulthood. Behavioral (stress ratings) and psychophysiological data (skin conductance and heart rate) were collected alongside fMRI. Race-related differences were observed in behavioral (stress ratings), psychophysiological (heart rate), and neural (fMRI) responses to stress. Further, a significant relationship was observed between stress reactivity and ACEs. Importantly, adjusting for ACEs reduced race-related differences in stress reactivity (stress ratings and brain function), suggesting that the neurobehavioral response to stress may be shaped, in part, by ACEs. These findings provide new insight into the socioenvironmental factors that influence emotional function.

Indexed as

Adverse Childhood ExperiencesBrainStress, PsychologicalAdolescentAdultAmygdalaBlack or African AmericanBrain MappingEmotionsFemaleGalvanic Skin ResponseHeart RateHumansMagnetic Resonance ImagingMaleWhiteadverse childhood experiencesneuroimagingrace-related differencessocial neurosciencestress

Identifiers

PMID42216628

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.