Evidence map›Paper›PMID 42216701›Full record

ArticleMagnetic resonance in medicine2026

Atlas of Brain Glucose Metabolism Using Deuterium Metabolic Imaging at 3 T.

Kamilla K Trosborg, Nichlas V Christensen, Malene Aastrup, Nikolaj Bøgh, Janne K Mortensen, Hanne Gottrup, Per Borghammer, Mattias H Kristensen, Esben S S Hansen, Sofie H Christensen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kamilla K TrosborgThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0009-0004-1572-1473
Nichlas V ChristensenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-7390-6071
Malene AastrupThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Nikolaj BøghThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0321-3269
Janne K MortensenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Hanne GottrupDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Per BorghammerDepartment of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.
Mattias H KristensenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Esben S S HansenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-5512-9870
Sofie H ChristensenDepartment of Mathematics, Aarhus University, Aarhus, Denmark.
Jack J MillerThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Rolf F SchulteGE HealthCare, Munich, Germany.
Michael VaeggemoseThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-7666-6819
Lotte B BertelsenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Christoffer LaustsenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0317-2911

Funding

Lundbeck Foundation R272-2017-4023Novo Nordisk Fonden 0084906
6 · The paper itself

Abstract

purposeDeuterium metabolic imaging (DMI) offers noninvasive magnetic resonance imaging (MRI)-based assessment of metabolism in vivo, making it a relevant paraclinical tool for diseases with neurological metabolic alterations. This study aimed to establish a normative reference atlas of brain glucose metabolism accounting for age and sex.

methodsDMI were obtained for 30 healthy adults (aged 51-84 years, 15 female) with a 3 T MRI scanner after ingestion of deuterated [6,6'-

resultsRegional differences were significant for all metabolites (p < 10

conclusionsWhile regional and age effects explained a substantial part of the variability in Glx, reliable intersubject comparisons required additional adjustments. The normative atlas presented here provides a reference for future DMI studies of brain metabolism.

Indexed as

BrainDeuteriumGlucoseMagnetic Resonance ImagingAgedAged, 80 and overAlzheimer DiseaseFemaleHumansMaleMiddle AgedDeuteriumGlucoseAlzheimer's diseaseatlasbraindeuteriumglucose metabolismmagnetic resonance imaging

Identifiers

PMID42216701
PMCPMC13419004

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.