ArticleApplied microbiology and biotechnology2026
Glycerol-mediated improvement of heterologous aurachin D production in E. coli.
Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neglected tropical diseases and the increasing prevalence of antibiotic resistance in nosocomial infections represent a major challenge in medicine. Intensive research into bioactive compounds has identified the myxobacterial natural product aurachin D as promising drug candidate due to its potent antibiotic and antiprotozoal properties. The biosynthesis of aurachin D from 2-methyl-1H-quinolin-4-one (MQO) is catalyzed by the membrane-bound farnesyltransferase AuaA. Recently, this enzymatic conversion was reconstructed in the heterologous host Escherichia coli, yielding an aurachin D titer of 17 mg L
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