Evidence map›Paper›PMID 42217002›Full record

Observational studySurgery today2026

Impact of the number of colorectal cancer lymph node metastases on intraperitoneal lavage cytology: a multi-institutional, prospective, observational study.

Minori Mise, Heita Ozawa, Hirotoshi Kobayashi, Masayasu Kawasaki, Yukihide Kanemitsu, Yusuke Kinugasa, Hideki Ueno, Takeshi Suto, Michio Itabashi, Kimihiko Funahashi and 4 more

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Minori MiseDepartment of Surgery, Tochigi Cancer Center, 4-9-13 Yonan, Utsunomiya, Tochigi, Japan. tsc.ninja400@gmail.com.ORCID http://orcid.org/0009-0000-7205-1710
Heita OzawaDepartment of Surgery, Tochigi Cancer Center, 4-9-13 Yonan, Utsunomiya, Tochigi, Japan.
Hirotoshi KobayashiDepartment of Surgery, Teikyo University Hospital, Mizonokuchi, Kanagawa, Japan.
Masayasu KawasakiDepartment of Surgery, Bell Land General Hospital, Sakai, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.
Takeshi SutoDepartment of Gastroenterological Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Michio ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Kimihiko FunahashiDepartment of General and Gastroenterological Surgery, Toho University Omori Medical Center, Tokyo, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Kenjiro KotakeDepartment of Surgery, Sano City Hospital, Tochigi, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe previously identified T4, an undifferentiated histological type, and positive lymph node (LN) metastasis as risk factors for positive intraperitoneal lavage cytology (IPLC) in colorectal cancer (CRC) surgery. However, the number of LN metastases influencing IPLC positivity remains unknown. We conducted a multicenter, prospective, observational study to determine the threshold number of LN metastases associated with IPLC positivity and identify patients with CRC who should undergo IPLC.

methodsPatients with clinical stage II and III CRC who underwent tumor resection and IPLC between 2013 and 2017 were included. IPLC was performed once during laparotomy and once after tumor resection. Patients with a T4 stage, ascites, or undifferentiated types were excluded, as these factors affected IPLC. The number of LNs that influenced IPLC positivity was examined using a logistic regression analysis and the Akaike information criterion (AIC).

resultsThe IPLC positivity rate was 2.0%. The rate increased significantly in patients with ≥ 2 LN metastases, and stratification by five LN metastases yielded the lowest AIC value (156.9). The positivity rate was 8.9-fold higher in patients with ≥ 5 LN metastases than in those with < 5 metastases.

conclusionIPLC is recommended for patients with clinical stage III CRC and multiple LN metastases.

Indexed as

Colorectal NeoplasmsCytodiagnosisLymphatic MetastasisLymph NodesPeritoneal LavageAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingProspective StudiesRisk FactorsColorectal cancerIntraperitoneal lavage cytologyLymph nodeMetastases

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.