Evidence map›Paper›PMID 42217146›Full record

ArticleJapanese journal of ophthalmology2026

Transient increase in flicker ERG amplitude preceding OCT-detected macular thickening in eyes with acute anterior uveitis.

Kumiko Kato, Keitaro Mizumoto, Ryunosuke Nagashima, Mayumi Momose, Yuzen Kashima, Sumine Mori, Hisashi Matsubara, Mineo Kondo

Abstract read
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In one paragraph

Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kumiko KatoDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. k-kato@med.mie-u.ac.jp.ORCID http://orcid.org/0000-0003-4172-3443
Keitaro MizumotoDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Ryunosuke NagashimaDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Mayumi MomoseDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Yuzen KashimaDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Sumine MoriDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Hisashi MatsubaraDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the changes in amplitude of the flicker electroretinograms (ERGs) and central macular thickness (CMT) during the acute phase of acute anterior uveitis (AAU). STUDY

designRetrospective case series.

methodsFlicker ERGs (RETeval) and optical coherence tomographic (OCT) images were recorded from the affected and fellow eyes at multiple examination times. The outcomes are expressed as a ratio of the affected-to-fellow eyes (×100). The time courses were modeled by polynomial regression (degrees 1-4) with model selection based on R

resultsEight eyes from eight patients (4 men, 4 women; mean age 48.8±15.8 years) underwent 3.3±1.0 paired ERG/OCT assessments. The ratio of the amplitudes of the two eyes had a significant nonlinear time course, and a 4th-degree model was best supported (R

conclusionsThe flicker ERG amplitudes increase transiently around two weeks after the onset of AAU and subsequent macular thickening in the OCT images. These findings suggest that flicker ERGs may serve as an early functional retinal marker of subclinical posterior segment inflammation in eyes with AAU.

Indexed as

ElectroretinographyMacula LuteaTomography, Optical CoherenceUveitis, AnteriorAcute DiseaseAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesVisual AcuityAcute anterior uveitisAmplitudeCentral macular thicknessFlicker ERGInflammationOCT

Identifiers

PMID42217146
PMCPMC13616019

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.