Age-related changes to brain energetics revealed by PET/MRI imaging.

Connor W J Bevington, Sahib Dhaliwal, Jessamyn McKenzie, A Jon Stoessl, Vesna Sossi

Abstract read

In one paragraph

Article in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Connor W J BevingtonDepartment of Physics and Astronomy, University of British Columbia, 325-6224 Agricultural Road, Vancouver, BC V6T 1Z1, Canada. Electronic address: bevington@phas.ubc.ca.

Sahib DhaliwalPacific Parkinson's Research Centre, University of British Columbia, Vancouver, BC, Canada. Electronic address: sahib.dhaliwal@ubc.ca.

Jessamyn McKenziePacific Parkinson's Research Centre, University of British Columbia, Vancouver, BC, Canada. Electronic address: jess.mckenzie@ubc.ca.

A Jon StoesslDepartment of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address: jon.stoessl@ubc.ca.

Vesna SossiDepartment of Physics and Astronomy, University of British Columbia, 325-6224 Agricultural Road, Vancouver, BC V6T 1Z1, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address: vesna@phas.ubc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is accompanied by several neurophysiological changes. Of recent interest are age-related changes in brain energetics-how the brain produces and uses energy. In vitro, preclinical, and genetic investigations point to a general decline in the efficiency of brain energetics in aging, which may help explain age-related changes in mood, cognition, movement, and behaviour, as well as an increased likelihood of developing neurodegenerative disorders. We hypothesized that age-related alterations to brain energetics are observable using functional neuroimaging data from healthy individuals (N = 24, 35-80 years), and that alterations may occur in regions associated with neurodegenerative pathology. Specifically, we jointly analyzed cerebral glucose metabolism and blood flow data, defining novel metrics that capture regional variability in processes related to relative energy production (rEP) and relative aerobic glycolysis (rAG), an energy production mechanism. By applying Scaled Subprofile Modeling Principal Component Analysis (SSM-PCA) to these metrics, we identified spatial covariance patterns that capture a widespread age-related restructuring of brain energetics. Broadly, an age-related rEP pattern (r

Indexed as

AgingBrainEnergy MetabolismMagnetic Resonance ImagingPositron-Emission TomographyAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedAerobic glycolysisBrain energeticsHealthy agingNeurodegenerationPET/MRISpatial covariance analysis

Identifiers

PMID42217474

DOI10.1016/j.nicl.2026.104014

PMCPMC13241851

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.