ArticleAJNR. American journal of neuroradiology2026
Aneurysm Wall Enhancement in Patients With Unruptured Intracranial Aneurysm Using Aspirin or Statins: A Cross-Sectional Analysis of Three Prospective Cohorts.
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21 authors.
Pengjun JiangFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Yang LiuFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Xin NieFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Huiyou ChenFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Mervyn D I VergouwenFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Jun WuFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Yi YangFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Zheng WenFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Mahmud Mossa-BashaFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Michael R LevittFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Bing ZhaoFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Jinrui RenFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Xiaolin ChenFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Yisen ZhangFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Beibei SunFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Rina A GuoFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Shreya MundraFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Rong WangFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Shuo WangFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China. captain9858@126.com.
Qingyuan LiuFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Chengcheng ZhuFrom the Department of Neurosurgery (P.J., Y.L., X.N., Y.Y., Z.W., X.C., Y.Z., R.W., S. W., Q.L.), Beijing Tiantan Hospital, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical university, Beijing, China; Department of Radiology (H.C.), Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Neurology and Neurosurgery (M.D.I.V.), UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology (M.M.-B., M.R.L., B.S., C.Z.), Neurological Surgery (M.R.L.), Biology (R.A.G.), Global Health (S.M.), School of Public Health, University of Washington, Seattle, Washington, USA; Department of Neurosurgery (B.Z.), Renji Hospital, Radiology (B.S.), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (J.R.), Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China; Department of Interventional Neuroradiology (Y.Z.), Beijing Neurosurgical Institute, Capital Medical university, Beijing, China and China National Clinical Research Center for Neurological Diseases (NCRC-ND) (S.W.), Beijing, China.
Funding
Investigation of the quantitative intracranial aneurysm wall enhancement and geometric features associated with aneurysm volume growthR01HL162743 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$492kNHLBI NIH HHS R01 HL162743
Abstract
objectiveTo investigate the association between use of aspirin or statins and aneurysm wall enhancement (AWE) on 3T magnetic resonance vessel wall imaging (MR-VWI) in patients with unruptured intracranial aneurysms (UIAs).
methodsFor this cross-sectional study, we obtained individual patient data from three prospective UIA follow-up registries in which patients underwent 3.0T MR-VWI. Regular medication use was defined as aspirin ≥100 mg at least three times per week for ≥6 months, and statins at ≥20 mg daily for ≥6 months. AWE was classified as no AWE (no visible enhancement), focal AWE (enhancement limited to part of the aneurysm wall), or circumferential AWE (enhancement involving the entire wall). Multivariable ordinal logistic regression was used to assess the association between medication use and AWE in the full cohort. To isolate the effect of each drug, we conducted two separate propensity score matching analyses (PSM): statin users were excluded from the aspirin analysis, and aspirin users from the statin analysis. Logistic regression analyses were repeated within each matched group.
resultsWe included 1351 patients with 1416 UIAs, of whom 141 (10.4%) used aspirin and 145 (10.7%) used statin. In the full cohort, multivariable ordinal logistic regression showed that aspirin use was associated with a lower likelihood of AWE (OR=0.51; 95%CI, 0.35-0.74), whereas statin use was not significantly associated with AWE (OR=1.44; 95% CI, 0.98-2.12). PSM based on age, sex, hypertension, diabetes, dyslipidemia, and aneurysm size yielded 83 matched pairs in the aspirin cohort and 97 in the statin cohort. In the matched cohorts, aspirin use remained inversely associated with AWE (OR=0.47; 95% CI, 0.26-0.85), while statin use remained unassociated (OR=1.49; 95% CI, 0.88-2.50).
conclusionIn this cross-sectional analysis, aspirin use was independently associated with reduced AWE in patients with UIAs, while statin use was not. However, the cross-sectional design precludes causal inference regarding a direct anti-inflammatory effect on the aneurysm wall.
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Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.