Evidence map›Paper›PMID 42219133›Full record

ReviewNeuroscience and biobehavioral reviews2026

Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.

Raquel Kosted, Manoj K Doss, Jennifer J Donegan, Josh M Cisler, Gregory A Fonzo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raquel KostedInterdisciplinary Neuroscience Program, The University of Texas at Austin, 110 Inner Campus Drive, Austin, TX 78705, United States; Charmaine & Gordon McGill Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Bldg. B, Stop Z0600, Austin, TX 78712, United States. Electronic address: raquel.kosted@austin.utexas.edu.
Manoj K DossCharmaine & Gordon McGill Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Bldg. B, Stop Z0600, Austin, TX 78712, United States.
Jennifer J DoneganCharmaine & Gordon McGill Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Bldg. B, Stop Z0600, Austin, TX 78712, United States.
Josh M CislerCharmaine & Gordon McGill Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Bldg. B, Stop Z0600, Austin, TX 78712, United States.
Gregory A FonzoCharmaine & Gordon McGill Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Bldg. B, Stop Z0600, Austin, TX 78712, United States.

Funding

Neurochemical & Behavioral Correlates of ETOH EffectsT32AA007471 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI Kimberly Nixon · 1987 to 2026
$9.2M
1/2 Neurodevelopmental and clinical trajectories of youth at risk for bipolar I disorderR01MH125886 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI ALMEIDA, JORGE R C, STRAKOWSKI, STEPHEN M · 2021 to 2025
$4.3M
Establishing Multimodal Brain Biomarkers Using Data-driven Analyticsfor Treatment Selection in DepressionR01MH129694 · NIMH · STANFORD UNIVERSITY · PI Yu Zhang · 2023 to 2026
$2.8M
Alcohol, Approach-Avoidance, and Neurocircuitry Interactions in PTSDR01AA030740 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Joshua M Cisler, Elizabeth Thomas Cox Lippard · 2023 to 2026
$2.7M
Computational Biases of Learning and Decision-Making in PTSDR01MH119132 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CISLER, JOSHUA M · 2019 to 2023
$2.6M
The effects of trauma-focused psychotherapy on reward circuitry function and information encodingR01MH132784 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Gregory Fonzo · 2024 to 2026
$2.3M
Using Exercise to Enhance Consolidation of Exposure-Based Therapeutic Learning in PTSDR61MH132722 · NIMH · UNIVERSITY OF KENTUCKY · PI ADAMS, THOMAS G, BADOUR, CHRISTAL L. · 2024 to 2025
$2.1M
Efficacy and mechanisms of exercise-enhanced fear extinctionR01MH137445 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Joshua M Cisler, Joseph Edward Dunsmoor · 2025 to 2026
$1.5M
Interneurons differentially regulate discrete pathways from ventral hippocampusR00MH121355 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI DONEGAN, JENNIFER · 2021 to 2023
$825k
Interneurons differentially regulate discrete pathways from ventral hippocampusK99MH121355 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DONEGAN, JENNIFER · 2019 to 2020
$239k
NIAAA NIH HHS R01 AA030740NIAAA NIH HHS T32 AA007471NIMH NIH HHS K99 MH121355NIMH NIH HHS R00 MH121355NIMH NIH HHS R01 MH119132NIMH NIH HHS R01 MH125886NIMH NIH HHS R01 MH129694NIMH NIH HHS R01 MH132784NIMH NIH HHS R01 MH137445NIMH NIH HHS R61 MH132722
6 · The paper itself

Abstract

Although research on psychedelics (hallucinogenic serotonin 2 A or 5-HT

Indexed as

Cognitive FlexibilityHallucinogensLearningReversal LearningRewardAnimalsHumansHallucinogensBehavioral flexibilityCognitive flexibilityPsychedelicsReversal learningReward learningSerotoninSet-shifting

Identifiers

PMID42219133
PMCPMC13331243

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.